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Titolo:
Curariform peripheral block of muscular tone selectively increases precentral N30 somatosensory evoked potentials component. A pharmacological study carried out on healthy subjects and parkinsonian syndromes
Autore:
Pierantozzi, M; Sabato, AF; Leonardis, F; Marciani, MG; Cicardi, C; Giacomini, P; Bernardi, G; Stanzione, P;
Indirizzi:
Univ Roma Tor Vergata, Neurol Clin, Rome, Italy Univ Roma Tor Vergata Rome Italy Tor Vergata, Neurol Clin, Rome, Italy Osped Santa Lucia, IRCCS, Rome, Italy Osped Santa Lucia Rome ItalyOsped Santa Lucia, IRCCS, Rome, Italy Univ Roma Tor Vergata, Cattedra Anestesia, Rome, Italy Univ Roma Tor Vergata Rome Italy rgata, Cattedra Anestesia, Rome, Italy Opsed S Eugenio ASL RMC, Dipartimento Psichiatria, Rome, Italy Opsed S Eugenio ASL RMC Rome Italy ipartimento Psichiatria, Rome, Italy Univ Rome La Sapienza, Ist Clin Malattie Nervose & Mentali, Rome, Italy Univ Rome La Sapienza Rome Italy alattie Nervose & Mentali, Rome, Italy
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 3, volume: 133, anno: 2000,
pagine: 368 - 376
SICI:
0014-4819(200008)133:3<368:CPBOMT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC MALIGNANT SYNDROME; INDUCED TRANSIENT POTENTIATION; FRONTAL COMPONENTS; PRIMING PRINCIPLE; ACTIVE MOVEMENT; DISEASE; PARIETAL; STIMULATION; RESPONSES; LESIONS;
Keywords:
somatosensory evoked potential cortical; components; atracurium besilate; rigidity; Parkinson's disease; dopaminergic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Pierantozzi, M Univ Roma Tor Vergata, Neurol Clin, Rome, Italy Univ Roma Tor Vergata Rome Italy eurol Clin, Rome, Italy
Citazione:
M. Pierantozzi et al., "Curariform peripheral block of muscular tone selectively increases precentral N30 somatosensory evoked potentials component. A pharmacological study carried out on healthy subjects and parkinsonian syndromes", EXP BRAIN R, 133(3), 2000, pp. 368-376

Abstract

In the present study we investigated whether the precentral component (N30) of short somatosensory evoked potentials (SEPs) to median nerve stimulation may be modified by peripheral neuromuscular blocking agent in patients affected by rigidity. We, therefore, recorded SEPs in nine Parkinson's disease (PD) patients and in seven psychotic patients affected by neuroleptic malignant syndrome (NMS), all showing severe rigidity. Each patient group wasstudied before and after the placebo, and before and after an atracurium besilate bolus of 0.05 mg/kg, in a single recording session. At the time of the test the PD patients had not taken any antiparkinsonian therapy for at least 48 h. The same recordings were also taken on nine neurologically normal subjects undergoing surgical procedures. Atracurium administration produced a remarkable amplitude increase of the major precentral component (N30)of SEPs. An atracurium-induced N30 amplitude increase was observed in bothPD patients (from 2.41 to 4.07 mu V) and NMS psychotic patients (from 2.03to 3.97 mu V), whereas there was a minor N30 amplitude increase in healthysubjects (from 3.53 to 4.10 mu V). The N30 latency was unaffected. Amplitude and latency of the major parietal SEPs component (N20) was unchanged in the three groups studied. Our results lead to the conclusion that a neuromuscular blocking agent is capable of increasing the N30 amplitude in patients affected by severe rigidity, exclusively reducing their muscular tone without interfering with the central dopaminergic system. Thus, a "peripheral gating" of sensory input to the supplementary motor area due to rigidity may play a relevant role in producing the N30 amplitude decrease described inpatients affected by degenerative or pharmacologically induced parkinsonism. The reduction of rigidity could be the mechanism by which dopamine may increase the precentral N30 amplitude in parkinsonian syndromes.

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Documento generato il 14/07/20 alle ore 08:39:04