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Titolo:
Involvement of the human medial cerebellum in long-term habituation of theacoustic startle response
Autore:
Maschke, M; Drepper, J; Kindsvater, K; Kolb, FP; Diener, HC; Timmann, D;
Indirizzi:
Univ Essen, Dept Neurol, D-45122 Essen, Germany Univ Essen Essen GermanyD-45122 en, Dept Neurol, D-45122 Essen, Germany Univ Munich, Dept Physiol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 , Dept Physiol, D-8000 Munich, Germany
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 3, volume: 133, anno: 2000,
pagine: 359 - 367
SICI:
0014-4819(200008)133:3<359:IOTHMC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETICULAR-FORMATION; DECEREBRATE RATS; REFLEX; VERMIS; SENSITIZATION; LESIONS; INHIBITION; BEHAVIOR; MEMORY; RABBIT;
Keywords:
cerebellum; acoustic startle response; habituation; non-associative motor learning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Maschke, M Univ Essen, Dept Neurol, Hufelandstr 55, D-45122 Essen, GermanyUniv Essen Hufelandstr 55 Essen Germany D-45122 Essen, Germany
Citazione:
M. Maschke et al., "Involvement of the human medial cerebellum in long-term habituation of theacoustic startle response", EXP BRAIN R, 133(3), 2000, pp. 359-367

Abstract

Animal studies have shown an involvement of the cerebellar vermis in long-term habituation of the acoustic startle response, but not in short-term habituation, The aim of the present study was to investigate whether short-term and long-term habituation of the acoustic startle response are impaired in patients with medial cerebellar lesions. Five patients with midline cerebellar lesions due to surgery for astrocytoma and ten healthy, age- and sex-matched subjects were studied. Subjects received 40 acoustic startle stimuli each day on five successive days. Peak amplitudes of the startle response recorded at the orbicularis oculi and the sternomastoid muscles were obtained. Data were analyzed for response decrement within the training sessionof one day (short-term habituation) and for a decrease in the startle response across the five training days (long-term habituation). Short- and long-term habituation of the startle response recorded at the sternomastoid muscles could be achieved in controls and in cerebellar patients. However, long-term habituation of the blink component of the acoustic startle response recorded at the orbicularis oculi muscles was significantly impaired in patients with cerebellar lesions compared with control subjects, whereas short-term habituation was preserved in both groups. The present findings suggest that the medial cerebellum is involved in long-term habituation of the blink component of the startle response in humans.

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Documento generato il 04/04/20 alle ore 12:29:03