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Titolo:
Altered energy metabolism after myocardial infarction assessed by P-31-MR-spectroscopy in humans
Autore:
Beer, M; Sandstede, J; Landschutz, W; Viehrig, M; Harre, K; Horn, M; Meininger, M; Pabst, T; Kenn, W; Haase, A; von Kienlin, M; Neubauer, S; Hahn, D;
Indirizzi:
Univ Wurzburg, Inst Rontgendiagnost, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 agnost, D-97080 Wurzburg, Germany Univ Wurzburg, Phys Inst EP 5, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 t EP 5, D-97080 Wurzburg, Germany Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany
Titolo Testata:
EUROPEAN RADIOLOGY
fascicolo: 8, volume: 10, anno: 2000,
pagine: 1323 - 1328
SICI:
0938-7994(2000)10:8<1323:AEMAMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; CARDIAC PHOSPHORUS METABOLITES; PHOSPHATE-METABOLISM; NMR-SPECTROSCOPY; HEART-FAILURE; VIABILITY; LOCALIZATION; DYSFUNCTION; RATIOS;
Keywords:
heart; ischaemia; MR imaging; MR spectroscopy; high-energy phosphates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Beer, M Univ Wurzburg, Inst Rontgendiagnost, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 many
Citazione:
M. Beer et al., "Altered energy metabolism after myocardial infarction assessed by P-31-MR-spectroscopy in humans", EUR RADIOL, 10(8), 2000, pp. 1323-1328

Abstract

The value of P-31-magnetic resonance spectroscopy (MRS) as a possible toolto distinguish viable from non-viable tissue after myocardial infarction was analysed in humans. Fifteen patients 3 weeks after anterior myocardial infarction were studied with breath-hold cine MRI and 3D-CSI MRS (1.5 T system). P-31-spectra were obtained from infarcted as well as non-infarcted myocardium (voxel size 25 cm(3) each). Gold standard for viability was recovery of regional function, as determined by a control MRI 6 months after revascularization. Ten age matched healthy volunteers served as control group. No significant difference was found between the; phosphocreatine to adenosinetriphosphate (PCr/ATP) ratio of volunteers (SD 1.72 +/- 0.31) and non-infarcted septal myocardium of patients. Cine MRI demonstrated recovery of regional function in 10 patients, i.e. 10 patients showed viable and 5 non-viable myocardium. In viable myocardium, the PCr/ATP ratio was 1.47 +/- 0.38 (non-significant vs volunteers; p > 0.05). In the 5 patients with akinetic myocardium, PCr peaks could not be detected. Therefore, calculation of PCr/ATP ratios was not possible. However, a significant reduction of the ATP signal-to-noise ratio (SNR) was observed (2.92 +/- 0.73 vs 6.68 +/- 0.80; patients vs volunteers; p <0.05). The SNR of ATP of akinetic regions may predictrecovery of function after revascularization in patients with myocardial infarction.

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Documento generato il 27/09/20 alle ore 17:43:51