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Titolo:
Erectile dysfunction: from biochemical pharmacology to advances in medicaltherapy
Autore:
Maggi, M; Filippi, S; Ledda, F; Magini, A; Forti, G;
Indirizzi:
Univ Florence, Dept Clin Physiopathol, Androl Unit, I-50139 Florence, Italy Univ Florence Florence Italy I-50139 ndrol Unit, I-50139 Florence, Italy Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy UnivFlorence Florence Italy I-50139 Pharmacol, I-50139 Florence, Italy
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 143, anno: 2000,
pagine: 143 - 154
SICI:
0804-4643(200008)143:2<143:EDFBPT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAVERNOSUM SMOOTH-MUSCLE; VASOACTIVE INTESTINAL POLYPEPTIDE; RABBIT CORPUS CAVERNOSUM; PENILE RESISTANCE ARTERIES; GENE-RELATED PEPTIDE; NITRIC-OXIDE-DONOR; SILDENAFIL CITRATE; YOHIMBINE HYDROCHLORIDE; DOUBLE-BLIND; LINSIDOMINE CHLORHYDRATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Maggi, M Univ Florence, Dept Clin Physiopathol, Androl Unit, V Le G Pieraccini 6, I-50139 Florence, Italy Univ Florence V Le G Pieraccini 6 FlorenceItaly I-50139 , Italy
Citazione:
M. Maggi et al., "Erectile dysfunction: from biochemical pharmacology to advances in medicaltherapy", EUR J ENDOC, 143(2), 2000, pp. 143-154

Abstract

Research on penile smooth muscle physiology has increased the number of drugs available for treating erectile dysfunction (ED. Penile erection involves the relaxation of smooth muscle in the corpus cavernosum. The key mediator of smooth muscle relaxation is nitric oxide (NO), which acts by increasing the cellular level of cGMP. Another cyclic nucleotide, cAMP, is involvedin smooth muscle cell relaxation; cAMP formation is stimulated by a numberof compounds, such as alprostadil, An increase in cAMP and/or cGMP levels can also be induced by inhibition of phosphodiesterases (PDEs), the enzymesinvolved in cyclic nucleotide breakdown. Both papaverine and sildenafil are PDE inhibitors. Papaverine is a non-specific inhibitor of these enzymes; sildenafil is an orally active, potent and selective inhibitor of GMP-specific PDE5, the predominant isoenzyme metabolizing cGMP in the cells of the corpus cavernosum. Penile smooth muscle contraction, induced by adrenergic fibers through alpha(1) adrenoceptors, produces detumescence, thus malting oc adrenoceptor antagonists suitable for maintenance of penile erection. Theorally active drug yohimbine is a mixed alpha(1)-alpha(2) adrenoceptor antagonist that works by a dual mechanism; it facilitates sexual arousal by acting on cut adrenoceptors in the central nervous system and blocks adrenergic influences at peripheral level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:05:31