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Titolo:
Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up
Autore:
Rust, C; Rau, H; Gerbes, AL; Pape, GR; Haller, M; Kramling, HJ; Schildberg, FW; Paumgartner, G; Beuers, U;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Internal Med 2, Munich, Germany Univ Munich Munich Germany hadern, Dept Internal Med 2, Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Surg, Munich, Germany Univ MunichMunich Germany ikum Grosshadern, Dept Surg, Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Anesthesiol, Munich, Germany Univ Munich Munich Germany osshadern, Dept Anesthesiol, Munich, Germany
Titolo Testata:
DIGESTION
fascicolo: 1, volume: 62, anno: 2000,
pagine: 38 - 43
SICI:
0012-2823(2000)62:1<38:LTIPBC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE LOSS; PROGNOSIS; MODEL; DISEASE; TIME;
Keywords:
liver transplantation; primary biliary cirrhosis; prognostic models; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Beuers, U Univ Munich, Klinikum Grosshadern, Dept Med 2, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 h, Germany
Citazione:
C. Rust et al., "Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up", DIGESTION, 62(1), 2000, pp. 38-43

Abstract

Background/Aims: Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, fewdata exist on the long-term survival. The optimal timing of transplantation is difficult. Thus, the aims of this study were to assess the long-term survival of patients with PBC after LTx and to identify potential predictivefactors for a positive outcome. Methods: Survival of 28 patients with PBC who underwent LTx between 1985 and July 1999 in a single center was studiedby Kaplan-Meier analysis and was compared to predicted survival without LTx using established prognostic models for PBC, the Mayo and European risk scores. Potential prognostic parameters obtained before LTx were tested for correlation to survival. Rates of bone fractures as markers of hepatic osteodystrophy were compared before and after LTx. Results: Median follow-up after LTx was 90 months with a maximum of 140 months. Actuarial survival of patients with PBC was 89% after 1, 5, and 10 years and was significantly better than estimated survival without LTx after 1-7 years as calculated by the Mayo and European risk scores. Of several parameters tested, only serum bilirubin and the prognostic scores, but no other liver function tests obtained immediately prior to transplantation were significantly correlated withsurvival after LTx. The duration of intensive care after LTx was not associated with any parameters obtained before LTx. Bone fractures were diagnosed in 43% of patients of whom the vast majority were osteopenic before LTx as determined by osteodensitometry. Conclusion: Longterm survival of a well-defined group of patients with PBC was excellent after LTx and was inversely correlated with preoperative serum bilirubin levels as well as Mayo and European risk scores. Copyright (C) 2000 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:30:40