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Titolo:
Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction
Autore:
Xu, RH; Peng, Y; Fan, J; Yan, DH; Yamagoe, S; Princler, G; Sredni, D; Ozato, K; Kung, HF;
Indirizzi:
Univ Wisconsin, Wisconsin Alumni Res Fdn, WiCell Res Inst, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 iCell Res Inst, Madison, WI 53705 USA NCI, Basic Res Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr,NIH, Frederick, MD 21701 USA NCI Frederick MD USA 21701 anc Res & Dev Ctr,NIH, Frederick, MD 21701 USA NICHHD, Lab Cellular & Mol Biophys, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 r & Mol Biophys, NIH, Bethesda, MD 20892 USA Bar Ilan Univ, Canc Aids & Immunol Res Inst, Interdisciplinary Dept, RamatGan, Israel Bar Ilan Univ Ramat Gan Israel Interdisciplinary Dept, RamatGan, Israel NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 Growth Regulat, NIH, Bethesda, MD 20892 USA Univ Hong Kong, Inst Mol Biol, Pokfulam, Hong Kong, Peoples R China Univ Hong Kong Pokfulam Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 4, volume: 218, anno: 2000,
pagine: 628 - 635
SICI:
1058-8388(200008)218:4<628:HAIACI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; EARLY XENOPUS DEVELOPMENT; FIBROBLAST GROWTH-FACTOR; TRANSCRIPTIONAL REPRESSION; EMBRYONIC-DEVELOPMENT; MAP KINASE; DEACETYLASE; EXPRESSION; HOMOLOG; INVOLVEMENT;
Keywords:
histone; acetylation; FGF; trichostatin A; activator protein 1; mesoderm; Xenopus; embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, RH Univ Wisconsin, Wisconsin Alumni Res Fdn, WiCell Res Inst, 614 Walnut St, Madison, WI 53705 USA Univ Wisconsin 614 Walnut St Madison WI USA 53705 son, WI 53705 USA
Citazione:
R.H. Xu et al., "Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction", DEV DYNAM, 218(4), 2000, pp. 628-635

Abstract

We have previously demonstrated that the transcription factor, AP-1 (c-jun/c-fos heterodimer), mediates fibroblast growth factor (FGF) signaling during mesoderm induction in Xenopus embryo. In the present studies, we show that histone acetylation is involved in FGF-mediated signaling leading to mesoderm induction, Histone acetylation is a dynamic process regulated by the activities of two histone-modifying enzymes, the histone acetyltransferase(s) and histone deacetylase(s) (HDACs), We found that basal and FGF-regulated activator protein 1 (AP-1) activity in Xenopus embryo is markedly reducedby treatment of trichostatin A (TSA), a specific inhibitor of HDAC. However, activity of another transcription factor, NF kappa B, is enhanced by TSAtreatment. AP-1-mediated mesoderm induction in the animal caps is dramatically suppressed by TSA at a dose-dependent manner. This suppression can be rescued by ectopic expression of HDAC3 at early stage, Finally, are found that histone acetylation in animal caps is inhibited by FGF whereas enhancedby TSA las It control). Therefore, we propose that histone acetylation is a checkpoint for transduction of the FGF/AP-1 signals to induce mesoderm, Published 2000 Wiley-Liss, Inc.dagger.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:47:43