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Titolo:
How high-density lipoprotein protects against the effects of lipid peroxidation
Autore:
Mackness, MI; Durrington, PN; Mackness, B;
Indirizzi:
Univ Manchester, Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England Univ Manchester Manchester Lancs England M13 9WL M13 9WL, Lancs, England
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 4, volume: 11, anno: 2000,
pagine: 383 - 388
SICI:
0957-9672(200008)11:4<383:HHLPAT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATING-FACTOR-ACETYLHYDROLASE; CORONARY-ARTERY DISEASE; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; SERUM PARAOXONASE ACTIVITY; HEART-DISEASE; OXIDATIVE MODIFICATION; MYOCARDIAL-INFARCTION; OXIDIZED PHOSPHOLIPIDS; GENE-TRANSFER; A-I;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Mackness, MI Univ Manchester, Manchester Royal Infirm, Dept Med, Oxford Rd, Manchester M13 9WL, Lancs, England Univ Manchester Oxford Rd Manchester Lancs England M13 9WL nd
Citazione:
M.I. Mackness et al., "How high-density lipoprotein protects against the effects of lipid peroxidation", CURR OP LIP, 11(4), 2000, pp. 383-388

Abstract

The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the majormechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL, The hydrolysis of lipid peroxides by PON1 makes a major contribution to this effect of HDL. Evidence is accumulating that the PON1 activity of human serum can be modulated by a variety of natural compounds and that these may increase or decrease the protective ability of PON1 and therefore of HDL on which it is exclusively located. Modulations of PON1 that enhance its activity may help to delay the atherosclerotic process. Curr Opin Lipidol 11:383-388. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:09:47