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Titolo:
Immunorestitution disease involving the innate and adaptive response
Autore:
Cheng, VCC; Yuen, KY; Chan, WM; Wong, SSY; Ma, ESK; Chan, RMT;
Indirizzi:
Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China Queen Mary Hosp, Intens Care Unit, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 6, volume: 30, anno: 2000,
pagine: 882 - 892
SICI:
1058-4838(200006)30:6<882:IDITIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; MARROW TRANSPLANT RECIPIENTS; HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC DISSEMINATED CANDIDIASIS; FULMINANT HEPATIC-FAILURE; POLYMERASE CHAIN-REACTION; HIV COMBINATION THERAPY; ALLOGENEIC BONE-MARROW; CYTOMEGALOVIRUS RETINITIS; PROTEASE-INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Yuen, KY Univ Hong Kong, Dept Microbiol, Div Infect Dis, Queen Mary Hosp, Univ Pathol Bldg,Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Univ Pathol Bldg,Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
V.C.C. Cheng et al., "Immunorestitution disease involving the innate and adaptive response", CLIN INF D, 30(6), 2000, pp. 882-892

Abstract

Immunorestitution disease (IRD) is defined as an acute symptomatic or paradoxical deterioration of a (presumably) preexisting infection that is temporally related to the recovery of the immune system. We report the temporal sequence of events that led to IRD caused by Pneumocystis carinii and Aspergillus terreus in 2 human immunodeficiency virus (HIV)-negative patients soon after the recovery of adaptive and innate immunity, respectively, and wereview episodes noted in the English-language literature that fit the definition of IRD (109 episodes in 107 patients). The median time from the recovery of neutrophil counts or termination of steroid therapy to the development of IRD was 8 days in cases of pulmonary aspergillosis (23 episodes) andhepatosplenic candidiasis (8) and 21 days for viral diseases such as hepatitis B (24) and viral pneumonitis (6), For IRD due to mycobacteriosis (27 episodes) and cryptococcosis (4) in HIV-positive patients, the median interval between the initiation of highly active antiretroviral therapy (HAART) and the onset of IRD was 11 days; for viral infections, including those due to cytomegalovirus (14), hepatitis B virus (1), and hepatitis C virus (2), the median interval was 42 days, As an emerging clinical entity, IRD meritsfurther study to optimize treatment of immunosuppressed patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:07:52