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Titolo:
PROTEIN-KINASE-C IN THE POSTMORTEM BRAIN OF TEENAGE SUICIDE VICTIMS
Autore:
PANDEY GN; DWIVEDI Y; PANDEY SC; CONLEY RR; ROBERTS RC; TAMMINGA CA;
Indirizzi:
UNIV ILLINOIS,DEPT PSYCHIAT,1601 W TAYLOR CHICAGO IL 60612 MARYLAND PSYCHIAT RES CTR BALTIMORE MD 21228
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 228, anno: 1997,
pagine: 111 - 114
SICI:
0304-3940(1997)228:2<111:PITPBO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2 RECEPTOR-BINDING; CEREBROSPINAL-FLUID; MONOAMINE METABOLITES; ALZHEIMERS-DISEASE; BLOOD-PLATELETS; RAT-BRAIN; DEPRESSION; MELANCHOLIA; HIPPOCAMPUS; DECREASES;
Keywords:
PROTEIN KINASE C; POSTMORTEM BRAIN; TEENAGE SUICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Pandey et al., "PROTEIN-KINASE-C IN THE POSTMORTEM BRAIN OF TEENAGE SUICIDE VICTIMS", Neuroscience letters, 228(2), 1997, pp. 111-114

Abstract

Increased serotonin(2A) (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signalingcascade, we determined [H-3]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and9) obtained from teenage suicide victims and control subjects. [H-3]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B-max of [H-3]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:16:07