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Titolo:
Regeneration of mouse lip epidermis after cryo treatment - Hemidesmosome formation and HSPG (heparan sulfate proteoglycan) distribution in basement membrane
Autore:
Osawa, T; Abe, M; Wang, Y; Nozaka, Y;
Indirizzi:
Iwate Med Univ, Sch Dent, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 1, volume: 167, anno: 2000,
pagine: 9 - 17
SICI:
1422-6405(2000)167:1<9:ROMLEA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL BASAL LAMINA; ALLOGENEIC NERVE GRAFTS; HUMAN SKIN; ULTRASTRUCTURAL-LOCALIZATION; FIBRONECTIN; RAT; ORGANIZATION; ATTACHMENT; MIGRATION; CARCINOMA;
Keywords:
lip epidermis; regeneration; basement membrane; heparan sulfate proteoglycan; hemidesmosome; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Osawa, T Iwate Med Univ, Sch Dent, Morioka, Iwate 0208505, Japan Iwate MedUniv Morioka Iwate Japan 0208505 Iwate 0208505, Japan
Citazione:
T. Osawa et al., "Regeneration of mouse lip epidermis after cryo treatment - Hemidesmosome formation and HSPG (heparan sulfate proteoglycan) distribution in basement membrane", CELLS T ORG, 167(1), 2000, pp. 9-17

Abstract

The processes of degeneration and the regeneration of the lip epidermal cells was observed by electron microscopy, focussing on the substance and thestructure of the lamina lucida, on which regenerating cells migrated. After the repetitive freezing and thawing treatment, epidermal cells degenerated and detached from the dermis. The separation occurred between the epidermal cells and the basement membrane, leaving a small amount of cell debris on the lamina densa. After the separation of the epidermis, there were some thick parts in the lamina densa which appeared to be the part below hemidesmosomes. Regenerating epidermal cells migrated from the nondegenerated areaalong the cellular surface of the old lamina densa. They migrated over thecell debris which was gradually phagocitized, and formed new hemidesmosomes with the old lamina densa. Regenerating epidermal cells did not make close contact with the old lamina densa during their migration, but there was aclear space in between, indicating that some of the materials and the structure of the lamina lucida of the old basement membrane was preserved. By immunoelectron microscopy using anti-HSPG (heparan sulfate proteoglycan) antibody, it became clear that after the epidermal separation, HSPG was preserved in the basement membrane to some extent, especially in the thick parts of the lamina densa located below. The immunoelectron micrographs support the view that hemidesmosomes may reform at the previous locations at the oldlamina densa. Copyright(C)2000S.KargerAG.Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:54:45