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Titolo:
DOPAMINE D2 RECEPTORS IN SIGNAL-TRANSDUCTION AND BEHAVIOR
Autore:
PICETTI R; SAIARDI A; SAMAD TA; BOZZI Y; BAIK JH; BORRELLI E;
Indirizzi:
ULP,CNRS,INSERM,INST GENET & BIOL MOL & CELLULAIRE,BP163 F-67404 ILLKIRCH GRAFFENS FRANCE ULP,CNRS,INSERM,INST GENET & BIOL MOL & CELLULAIRE F-67404 ILLKIRCH GRAFFENS FRANCE YONSEI UNIV,COLL MED,MOL BIOL LAB,MED RES CTR SEOUL SOUTH KOREA CU STRASBOURG STRASBOURG FRANCE
Titolo Testata:
Critical reviews in neurobiology
fascicolo: 2-3, volume: 11, anno: 1997,
pagine: 121 - 142
SICI:
0892-0915(1997)11:2-3<121:DDRISA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; ANTERIOR-PITUITARY-CELLS; INSITU HYBRIDIZATION HISTOCHEMISTRY; INOSITOL PHOSPHATE PRODUCTION; NUCLEOTIDE BINDING-PROTEIN; SITE-DIRECTED MUTAGENESIS; ARACHIDONIC-ACID CASCADE; BETA-ADRENERGIC-RECEPTOR; RAT LACTOTROPH CELLS; MESSENGER-RNA;
Keywords:
7 TRANSMEMBRANE DOMAIN G-PROTEIN-COUPLED RECEPTORS; BASAL GANGLIA; PHARMACOLOGY; SIGNAL TRANSDUCTION; KNOCKOUT; PARKINSONS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
129
Recensione:
Indirizzi per estratti:
Citazione:
R. Picetti et al., "DOPAMINE D2 RECEPTORS IN SIGNAL-TRANSDUCTION AND BEHAVIOR", Critical reviews in neurobiology, 11(2-3), 1997, pp. 121-142

Abstract

The dopamine D2 receptor belongs to the family of seven transmembranedomain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis of peptide hormones. Two alternatively spliced transcripts are generated from the D2 receptor gene and code for the D2L and D2S isoforms, which are 444 and 415 amino acids in length, respectively. These isoforms exhibit similar pharmacological characteristics and are expressed in the same cell types, with a ratio that normally favors expressionof the longer isoform. The D2L isoform differs from D2S by the insertion of 29 amino acids in the putative third intracellular loop of the receptor. This loop is involved in the coupling of the receptor to different G proteins. Experiments have shown that the D2 isoforms have different G-protein-coupling affinities, suggesting that these receptorsmight serve different functions in vivo. Additionally, this difference in coupling affinity could be a mechanism to amplify the signal transduced by the binding of dopamine to D2 receptors. Important insights into D2 receptor function in vivo have been obtained by knocking out the D2 gene in mice. The Parkinsonian-like phenotype of D2-null mice demonstrates the importance of the D2 receptor for locomotor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:23:00