Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety
Autore:
Bolliger, CT; Zellweger, JP; Danielsson, T; van Biljon, X; Robidou, A; Westin, A; Perruchoud, AP; Sawe, U;
Indirizzi:
Univ Basel Hosp, Dept Internal Med, Div Resp, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 sp, CH-4031 Basel, Switzerland CHUV, Univ Med Policlin, CH-1000 Lausanne, Switzerland CHUV Lausanne Switzerland CH-1000 oliclin, CH-1000 Lausanne, Switzerland Pharmacia & Upjohn Inc, Biostat, S-25109 Helsingborg, Sweden Pharmacia & Upjohn Inc Helsingborg Sweden S-25109 09 Helsingborg, Sweden
Titolo Testata:
BRITISH MEDICAL JOURNAL
fascicolo: 7257, volume: 321, anno: 2000,
pagine: 329 - 333
SICI:
0959-8138(20000805)321:7257<329:SRWONI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CESSATION; REPLACEMENT; HARM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bolliger, CT Univ Basel Hosp, Dept Internal Med, Div Resp, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 asel, Switzerland
Citazione:
C.T. Bolliger et al., "Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety", BR MED J, 321(7257), 2000, pp. 329-333

Abstract

Objectives To determine whether use of an oral nicotine inhaler can resultin long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe,Design Double blind, randomised, placebo controlled trial. Four month trial with a two year follow up. Setting Two university hospital pulmonary clinics in Switzerland. Participants 100 healthy volunteers, recruited through newspaper advertisements, willing to reduce their smoking but unable or unwilling to stop smoking immediately. Intervention Active or placebo inhaler as needed for up to 18 months, withparticipants encouraged to limit their smoking as much as possible. Main outcome measures Number of cigarettes smoked per day from week six toend point Decrease verified by a measurement of exhaled carbon monoxide ateach time point compared with measurement at baseline,Results At four months sustained reduction of smoking was achieved in 52 (26%) participants in the active group and 18 (9%) in the placebo group (P <0.001; Fisher's test). Corresponding figures after two years were 19 (9.5%) and 6 (3.0%) (P = 0.012),Conclusion Nicotine inhalers effectively and safely achieved sustained reduction in smoking over 24 months. Reduction with or without nicotine substitution may be a feasible first step towards smoking cessation in people notable or not willing to stop abruptly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:32:41