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Titolo:
Electrical stimulation of the midbrain tectum enhances dopamine release inthe frontal cortex
Autore:
Cuadra, G; Zurita, A; Macedo, CE; Molina, VA; Brandao, ML;
Indirizzi:
USP, FFCLRP, Dept Psicol, Lab Psicobiol, BR-14049901 Ribeirao Preto, Brazil USP Ribeirao Preto Brazil BR-14049901 BC-14049901 Ribeirao Preto, Brazil Univ Nacl Cordoba, Dept Farmacol, Fac Ciencias Quim, RA-5000 Cordoba, Argentina Univ Nacl Cordoba Cordoba Argentina RA-5000 , RA-5000 Cordoba, Argentina
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 52, anno: 2000,
pagine: 413 - 418
SICI:
0361-9230(20000715)52:5<413:ESOTMT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-DIHYDROXYPHENYLACETIC ACID DOPAC; RAT PREFRONTAL CORTEX; INFERIOR COLLICULUS; PERIAQUEDUCTAL GRAY; NEGATIVE REINFORCEMENT; DEFENSIVE REACTIONS; LATENT INHIBITION; NEURAL SUBSTRATE; SUBSTANTIA-NIGRA; INDUCED INCREASE;
Keywords:
inferior colliculus; DRAG; aversion; dopamine; frontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Brandao, ML USP, FFCLRP, Dept Psicol, Lab Psicobiol, Campus Av Bandeirantes 3900, BR-14049901 Ribeirao Preto, Brazil USP Campus Av Bandeirantes 3900 Ribeirao Preto Brazil BR-14049901 BC
Citazione:
G. Cuadra et al., "Electrical stimulation of the midbrain tectum enhances dopamine release inthe frontal cortex", BRAIN RES B, 52(5), 2000, pp. 413-418

Abstract

One widely used animal model of anxiety is the electrical stimulation of agiven structure supposed to be involved in the neural circuitry underlyingemotional behavior. Indeed, electrical stimulation of midbrain structures with substrates for the processing of fear-like responses, such as the dorsal periaqueductal gray matter (DPAG) or the inferior colliculus (IC), produces behavioral, sensorial and autonomic responses very similar to the defense reactions observed in environmental threatening situations. It has also been proposed that the required level of integration of all these components of the defense reaction needs an integrative process situated at higher brain level, as the prefrontal cortex, As a matter of fact, substantial cortical inputs to the midbrain tectum have already been found. In view of thisevidence, it seems important to know whether animals stimulated in the midbrain tectum would present neurochemical changes in the prefrontal cortex. To this end, we examined the temporal course of the effects of the electrical stimulation of the DPAG and IC on the dopamine (DA) release in the prefrontal cortex. Electrical stimulation of these structures was performed at the alertness (control) and escape thresholds. Electrical stimulation of theinferior colliculus at the escape threshold produced a long-lasting increase in the levels of corticofrontal dopamine in relation to these measurements in the control group. No significant changes in extracellular DA releasein this cortical area could be observed following DPAG electrical stimulation. These findings bring evidence for the involvement of dopamine of the frontal cortex in the setting up of adaptive responses to stressful situations generated at the inferior colliculus level. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:25:00