Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Severe oesophagitis after allogeneic bone marrow transplantation for Fanconi's anemia
Autore:
Yakoub-Agha, I; Damaj, G; Garderet, L; Bonnet, J; Devergie, A; Esperou, H; Ribaud, P; Socie, G; Gluckman, E;
Indirizzi:
Hop St Louis, Hematol Bone Marrow Transplantat Dept, F-75475 Paris 10, France Hop St Louis Paris France 10 Transplantat Dept, F-75475 Paris 10, France Hop St Louis, Dept Gastroenterol, AP HP, F-75475 Paris, France Hop St Louis Paris France F-75475 oenterol, AP HP, F-75475 Paris, France
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 2, volume: 26, anno: 2000,
pagine: 215 - 218
SICI:
0268-3369(200007)26:2<215:SOAABM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE CYCLOPHOSPHAMIDE; THORACOABDOMINAL IRRADIATION; HEPATIC COMPLICATIONS; ESOPHAGEAL STRICTURE; DIAGNOSIS;
Keywords:
Fanconi's anemia; allogeneic bone marrow transplantation; oesophageal stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gluckman, E Hop St Louis, Hematol Bone Marrow Transplantat Dept, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude VellefauxParis France 10 0, France
Citazione:
I. Yakoub-Agha et al., "Severe oesophagitis after allogeneic bone marrow transplantation for Fanconi's anemia", BONE MAR TR, 26(2), 2000, pp. 215-218

Abstract

Allogeneic bone marrow transplantation (BMT) is an effective treatment forFanconi's anemia (FA) but it requires a dose reduction of alkylating agents used for conditioning because of the increased sensitivity of FA cells toDNA cross-linking agents. Oesophageal damage has not previously been described as a complication after allogeneic BMT for this indication. We report five cases of severe oesophagitis with stenosis in patients transplanted for FA, It occurred either early, or more surprisingly, several years after BMT and could have easily been misdiagnosed. It could be explained by hypersensitivity of the FA mucosal cells to cytotoxic agents despite the reduced doses of cyclophosphamide and irradiation or to non diagnosed congenital abnormalities of the oesophagogastric junction. However, the evolution of theoesophageal disease was favorable in all, and none of the patients developed secondary cancer. Awareness of this complication will lead to earlier diagnosis and treatment of oesophageal stenosis and related malnutrition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:33:42