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Titolo:
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene
Autore:
Miyamori, I; Inaba, S; Hatakeyama, H; Taniguchi, N; Takeda, Y;
Indirizzi:
Fukui Med Univ, Dept Internal Med 3, Fukui, Japan Fukui Med Univ Fukui Japan Med Univ, Dept Internal Med 3, Fukui, Japan Kanazawa Univ, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa UnivKanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
BIOMEDICINE & PHARMACOTHERAPY
, volume: 54, anno: 2000, supplemento:, 1
pagine: 77S - 79S
SICI:
0753-3322(200006)54:<77S:IHAOAS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; HYPERTENSION; POTASSIUM; MODEL;
Keywords:
CYP11B2; idiopathic hyperaldosteronism; P450aldo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Miyamori, I Fukui Med Univ, Dept Internal Med 3, Shimoaizuki 23-1, Fukui, Japan Fukui Med Univ Shimoaizuki 23-1 Fukui Japan -1, Fukui, Japan
Citazione:
I. Miyamori et al., "Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene", BIOMED PHAR, 54, 2000, pp. 77S-79S

Abstract

We analyzed the CYP11B2, the gene encoding aldosterone synthase, in mononuclear leukocytes in eight patients with primary aldosteronism due to zona glomerulosa hyperplasia (idiopathic hyperaldosteronism) and compared the results with aldosterone-producing adenomas. In idiopathic hyperaldosteronism,aldosterone synthase activity was significantly increased in accordance with gene expression (P < 0.05), compared with aldosterone-producing adenomas. No genetic mutations were found in coding regions of DNA. The T (-344) C allele polymorphism was present in a similar frequency in the general population. In one patient with idiopathic hyperaldosteronism, de novo homozygous mutation in upstream of the 5' flanking region C (-463) T was detected, which cannot be explained by polymorphism. The pathophysiological significance of this mutation for aldosterone hypersecretion is not known. There wereno mutations in the known promoter sequences for angiotensin II related cis-segments. Possible contribution of co-regulators for angiotensin II-induced signalling pathway is discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 01/12/20 alle ore 10:56:48