Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene
Autore:
Li, DX; Burch, P; Gonzalez, O; Kashork, CD; Shaffer, LG; Bachinski, LL; Roberts, R;
Indirizzi:
Baylor Coll Med, Cardiol Sect, Dept Med, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 ect, Dept Med, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 274, anno: 2000,
pagine: 117 - 123
SICI:
0006-291X(20000721)274:1<117:MCEAAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN BETA-SUBUNIT; DILATED CARDIOMYOPATHY; INTERACTS; DICTYOSTELIUM; MUTATIONS; RECEPTOR; DATABASE; ENCODES; FAMILY; CHAIN;
Keywords:
WD-repeat protein; cDNA cloning; gene expression; developmental biology; chromosome mapping; membrane protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, R Baylor Coll Med, Cardiol Sect, Dept Med, 6550 Fannin,MS SM677, Houston, TX77030 USA Baylor Coll Med 6550 Fannin,MS SM677 Houston TX USA 77030 0 USA
Citazione:
D.X. Li et al., "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene", BIOC BIOP R, 274(1), 2000, pp. 117-123

Abstract

The WD-repeat proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as signal transduction, transcription, and proliferation. Here we report on the cloning and characterization of a novel human WD-repeat gene, WDR6, which encodes a protein of 1121 amino acids and contains 11 WD-repeat units. WDR6 is unique since its 11 WD repeats are clustered into two distinct groups separated by a putative transmembrane domain. The WDR6 gene was mapped to chromosome 15q21 by fluorescence in situ hybridization. Northern analysis demonstrated that WDR6 is ubiquitously expressed in human adult and fetal tissues. WDR6 is not homologous to any previously identified human WD-repeat genes including WDR1 through WDR5. However, it was found to have significant sequence similarity with Arabidopsis thaliana hypothetical protein T7B11.12, yeast putative elongation factor G, and probable membrane protein YPL183c. All of them have been defined as WD-repeat proteins. Therefore, WDR6 is a novel protein and probably belongs to a highly conserved subfamily of WD-repeat proteins in which T7B11.12 and YPL183c are its distantly related members. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:17:15