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Titolo:
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Autore:
Dagnino-Subiabre, A; Cassels, BK; Baez, S; Johansson, AS; Mannervik, B; Segura-Aguilar, J;
Indirizzi:
Univ Chile, Fac Med, ICBM, Programme Mol & Clin Pharmacol, Santiago 7, Chile Univ Chile Santiago Chile 7 amme Mol & Clin Pharmacol, Santiago 7, Chile Univ Chile, Fac Sci, Dept Chem, Santiago, Chile Univ Chile Santiago Chile iv Chile, Fac Sci, Dept Chem, Santiago, Chile Uppsala Univ, Biomed Ctr, Dept Biochem, SE-75123 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75123 t Biochem, SE-75123 Uppsala, Sweden Stockholm Univ, Wallenberg Lab, Biochem Toxicol Unit, SE-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden SE-10691 nit, SE-10691 Stockholm, Sweden
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 274, anno: 2000,
pagine: 32 - 36
SICI:
0006-291X(20000721)274:1<32:GTMCCO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID; POSSIBLE MARKERS; DT-DIAPHORASE; OXIDATION; AUTOXIDATION; AMINOCHROME; METABOLITES; REDUCTION;
Keywords:
dopamine; dopa; glutathione transferase; o-quinones; aminochrome; dopachrome; 5-S-cysteinyl-dopa; 5-S-cysteinyldopamine; neuromelanin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dagnino-Subiabre, A Univ Chile, Fac Med, ICBM, Programme Mol & Clin Pharmacol, Independencia 1027,Casilla 70000, Santiago 7, Chile Univ Chile Independencia 1027,Casilla 70000 Santiago Chile 7
Citazione:
A. Dagnino-Subiabre et al., "Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones", BIOC BIOP R, 274(1), 2000, pp. 32-36

Abstract

Human glutathione transferase M2-2 prevents the formation of neurotoxic aminochrome and dopachrome by catalyzing the conjugation of dopamine and dopao-quinone with glutathione. NMR analysis of dopamine and dopa o-quinone-glutathione conjugates revealed that the addition of glutathione was at C-5 to form 5-S-glutathionyl-dopamine and 5-S-glutathionyldopa, respectively. Both conjugates were found to be resistant to oxidation by biological oxidizing agents such as O-2, H2O2, and O-2(.-), and the glutathione transferase-catalyzed reaction can therefore serve a neuroprotective antioxidant function. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:05:33