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Titolo:
Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance
Autore:
Albuquerque, EX; Pereira, EFR; Mike, A; Eisenberg, HM; Maelicke, A; Alkondon, M;
Indirizzi:
Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Therapeut, Baltimore, MD 21201 USA Univ Fed Rio de Janeiro, CCS, ICB, Dept Farmacol Basica & Clin, BR-21944 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21944 e Janeiro, Brazil Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Neurosurg, Baltimore, MD 21201 USA Univ Mainz, Sch Med, Mol Microbiol Lab, Inst Physiol Chem & Pathobiochem, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 & Pathobiochem, D-55099 Mainz, Germany
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 113, anno: 2000,
pagine: 131 - 141
SICI:
0166-4328(200008)113:1-2<131:NNRISF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; HIPPOCAMPAL-NEURONS; CIGARETTE-SMOKING; GABA RELEASE; PHARMACOLOGICAL CHARACTERIZATION; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; NUCLEUS-ACCUMBENS; CEREBRAL-CORTEX; ACH RECEPTORS;
Keywords:
acetylcholine; choline; GABA; hippocampus; cerebral cortex; slices; human; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Albuquerque, EX Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, 655 W Baltimore St, Baltimore, MD 21201 USA Univ Maryland 655 W Baltimore StBaltimore MD USA 21201 SA
Citazione:
E.X. Albuquerque et al., "Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance", BEH BRA RES, 113(1-2), 2000, pp. 131-141

Abstract

The present report describes the participation of nicotinic receptors (nAChRs) in controlling the excitability of local neuronal circuitries in the rat hippocampus and in the human cerebral cortex. The patch-clamp technique was used to record responses triggered by the non-selective agonist ACh andthe alpha 7-nAChR-selective agonist choline in interneurons of human cerebral cortical acid rat hippocampal slices. Evidence is provided that functional alpha 7- and alpha 4 beta 2-like nAChRs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the CA1 field of therat hippocampus and in the human cerebral cortex and that activation of the different nAChR subtypes present in the preterminal/terminal areas of theinterneurons triggers the tetrodotoxin-sensitive release of GABA. Modulation by nAChRs of GABAergic transmission, which can result either in inhibition or disinhibition of pyramidal neurons. depends both on the receptor subtype present in the interneurons and on the agonist acting upon these receptors. Not only do alpha 7 nAChRs desensitize faster than alpha 4 beta 2 nAChRs, but also alpha 7 nAChR desensitization induced by ACh lasts longer thanthat induced by choline. These mechanisms, which appear to be retained across species, might explain the involvement of nAChRs in cognitive functionsand in such neurological disorders as Alzheimer's disease and schizophrenia. (C) 2000 Elsevicr Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:33:13