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Titolo:
Genetic and pharmacological strategies identify a behavioral function of neuronal nicotinic receptors
Autore:
Stitzel, JA; Lu, Y; Jimenez, M; Tritto, T; Collins, AC;
Indirizzi:
Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 113, anno: 2000,
pagine: 57 - 64
SICI:
0166-4328(200008)113:1-2<57:GAPSIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; GABA RELEASE; ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; RATS; MICE; ANTAGONISTS; HIPPOCAMPUS; SENSITIVITY; FACILITATION;
Keywords:
cytisine; nicotine; nicotinic receptors; seizure; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Stitzel, JA Univ Colorado, Inst Behav Genet, Campus Box 447, Boulder, CO 80309 USA Univ Colorado Campus Box 447 Boulder CO USA 80309 CO 80309 USA
Citazione:
J.A. Stitzel et al., "Genetic and pharmacological strategies identify a behavioral function of neuronal nicotinic receptors", BEH BRA RES, 113(1-2), 2000, pp. 57-64

Abstract

The studies outlined here used pharmacological and genetic approaches to attempt to identify the nicotinic receptors that modulate nicotine-induced seizures. Full-blown clonic-tonic seizures were induced by intracerebroventricular (i.c.v.) injection of nicotine, the alpha 4 beta 2 selective agonistABT-418 and the alpha 7-selective GTS-21. Cytisine, which is a partial agonist at alpha 4 beta 2-type receptors, produced partial seizures. DH beta Eand MLA did not block nicotine-induced seizures. Instead, both antagonistscaused seizures. Restriction fragment length polymorphisms (RFLPs) for thealpha 7 receptor were identified in two inbred strains (C3H and DBA) that differ in sensitivity to nicotine-induced seizures. F2 mice derived from a C3H x DBA cross that were homozygous for the C3H variant of the alpha 7 RFLP were more sensitive to nicotine-induced seizures than were F2 mice that were homozygous for the DBA RFLP. In a study that used RI strains derived from two selectively bred mouse lines (LS and SS), an association between sensitivity to nicotine-induced seizures and an RFLP associated with the alpha4 gene was found. These data support the assertion that both alpha 4 and alpha 7 receptor types are involved in modulating convulsions produced by nicotine. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:39:01