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Titolo:
Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years
Autore:
Ando, N; Ozawa, S; Kitagawa, Y; Shinozawa, Y; Kitajima, M;
Indirizzi:
Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 pt Surg, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 2, volume: 232, anno: 2000,
pagine: 225 - 232
SICI:
0003-4932(200008)232:2<225:IITROS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE DISSECTION; THORACIC ESOPHAGUS; 3-FIELD LYMPHADENECTOMY; CANCER; SURVIVAL; RESECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, N Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 okyo 1608582, Japan
Citazione:
N. Ando et al., "Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years", ANN SURG, 232(2), 2000, pp. 225-232

Abstract

ObjectiveTo document the clinicopathologic characteristics and survival of patientsundergoing esophagectomy for squamous carcinoma of the thoracic esophagus,and to examine the factors contributing to improvements in outcome noted in patients with advanced carcinoma. Summary Background DataJapanese and some Western surgeons recently have reported that radical esophagectomy with extensive lymphadenectomy conferred a survival advantage topatients with esophageal carcinoma. The factors contributing to this improvement in results have not been well defined. MethodsFrom 1981 to 1995, 419 patients with carcinoma of the thoracic esophagus underwent esophagectomy at the Keio University Hospital. The clinicopathologic characteristics and survival of patients treated between 1981 and 1987 were compared with those of patients treated between 1988 and 1995. Multivariate analysis using the Cox regression model was carried out to evaluate the impact of 15 variables on survival of patients with p stage IIa to IV disease. Several variables related to prognosis were examined to identify differences between the two time periods. ResultsThe 5-year survival rate for all patients was 40.0%. The 5-year survival rate was 17.7% for p stage IIa to IV patients treated during the earlier period and 37.6% for those treated during the latter period. The Cox regression model revealed seven variables to be important prognostic factors. Of these seven, three (severity of postoperative complications, degree of residual tumor, and number of dissected mediastinal nodes) were found to be significantly different between the earlier and latter periods. ConclusionsThe survival of patients undergoing surgery for advanced carcinoma (p stage IIa to IV) of the thoracic esophagus has improved during the past 15 years. The authors' data suggest that this improvement is due mainly to advances in surgical technique and perioperative management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:02:19