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Titolo:
The fate of hypoxic tissue on F-18-fluoromisonidazole positron emission tomography after ischemic stroke
Autore:
Read, SJ; Hirano, T; Abbott, DF; Markus, R; Sachinidis, JI; Tochon-Danguy, HJ; Chan, JG; Egan, GF; Scott, AM; Bladin, CF; McKay, WJ; Donnan, GA;
Indirizzi:
Univ Melbourne, Dept Med, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia pt Med, Melbourne, Vic, Australia Austin & Repatriat Med Ctr, Natl Stroke Res Inst, Melbourne, Vic, Australia Austin & Repatriat Med Ctr Melbourne Vic Australia ourne, Vic, Australia Austin & Repatriat Med Ctr, Ctr Positron Emiss Tomog, Melbourne, Vic, Australia Austin & Repatriat Med Ctr Melbourne Vic Australia ourne, Vic, Australia Austin & Repatriat Med Ctr, Ludwig Inst Canc Res, Melbourne, Vic, Australia Austin & Repatriat Med Ctr Melbourne Vic Australia ourne, Vic, Australia
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 2, volume: 48, anno: 2000,
pagine: 228 - 235
SICI:
0364-5134(200008)48:2<228:TFOHTO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
F-18 FLUOROMISONIDAZOLE; BLOOD-FLOW; INFARCTION; PENUMBRA; PET; RELIABILITY; THRESHOLDS; HANDICAP; VOLUMES; BABOON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Donnan, GA Austin & Repatriat Med Ctr, Natl Stroke Res Inst, Boronia Ctr, Level 1,Repat Campus,Bell St, W Heidelberg, Vic 3081, Australia Austin & Repatriat Med Ctr Level 1,Repat Campus,Bell St W Heidelberg Vic Australia 3081
Citazione:
S.J. Read et al., "The fate of hypoxic tissue on F-18-fluoromisonidazole positron emission tomography after ischemic stroke", ANN NEUROL, 48(2), 2000, pp. 228-235

Abstract

We studied 24 patients up to 51 hours after ischemic stroke using F-18-fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived, The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time, On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic Most of the tissue "initially affected" proceeded to infarction, We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the NationalInstitutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the "initially affected" volume, neurological deterioration during the first week after stroke with the proportion of the "initially affected" volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:47:57