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Titolo:
Pharmacokinetics of erythromycin estolate and erythromycin phosphate afterintragastric administration to healthy foals
Autore:
Lakritz, J; Wilson, WD; Marsh, AE; Mihalyi, JE;
Indirizzi:
Univ Calif Davis, Sch Vet Med, Dept Pathol, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 Med, Dept Pathol, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Microbiol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 , Dept Microbiol, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Immunol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 ed, Dept Immunol, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Med & Epidemiol, Davis, CA 95616 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 8, volume: 61, anno: 2000,
pagine: 914 - 919
SICI:
0002-9645(200008)61:8<914:POEEAE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; RHODOCOCCUS-EQUI PNEUMONIA; HORSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lakritz, J Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 rg, Columbia, MO 65211 USA
Citazione:
J. Lakritz et al., "Pharmacokinetics of erythromycin estolate and erythromycin phosphate afterintragastric administration to healthy foals", AM J VET RE, 61(8), 2000, pp. 914-919

Abstract

Objective - To determine pharmacokinetics and plasma concentrations of erythromycin and related compounds after intragastric administration of erythromycin phosphate and erythromycin estolate to healthy foals,Animals - 11 healthy 2- to 6-month-old foals. Procedure - Food was withheld from foals overnight before intragastric administration of erythromycin estolate (25 mg/kg of body weight; n = 8) and erythromycin phosphate (25 mg/kg; 7). Four foals received both drugs with 2 weeks between treatments. Plasma erythromycin concentrations were determined at various times after drug administration by use of high-performance liquid chromatography. Maximum plasma peak concentrations, time to maximum concentrations, area under plasma concentration versus time curves, half-life of elimination, and mean residence times were determined from concentrationversus time curves. Results - Maximum peak concentration of erythromycin A after administration of erythromycin phosphate was significantly greater than after administration of erythromycin estolate (2.9 +/- 1.1 mu g/ml vs 1.0 +/- 0.82 mu g/ml). Time to maximum concentration was shorter after administration of enythromycin phosphate than after erythromycin estolate (0.71 +/- 0.29 hours vs 1.7 +/- 1.2 hours). Concentrations of anhydroerythromycin A were significantly less 1 and 3 hours after administration of erythromycin estolate than after administration of erythromycin phosphate. Conclusions and Clinical Relevance - Plasma concentrations of erythromycinA remained > 0.25 mu g/ml (reported minimum inhibitory concentration for Rhodococcus equi) for at least 4 hours after intragastric administration of erythromycin phosphate or erythromycin estolate, suggesting that the recommended dosage for either formulation (25 mg/kg, q 6 h) should be adequate for treatment of R equi infections in foals.

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Documento generato il 10/07/20 alle ore 12:03:03