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Titolo:
Human first-trimester decidua vascular density: An immunohistochemical study using VE-cadherin and endoglin as endothelial cell markers
Autore:
Vailhe, B; Kapp, M; Dietl, J; Arck, P;
Indirizzi:
Humboldt Univ, Berlin, Germany Humboldt Univ Berlin GermanyHumboldt Univ, Berlin, Germany Univ Wurzburg, Frauenklin, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 auenklin, D-8700 Wurzburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 1, volume: 44, anno: 2000,
pagine: 9 - 15
SICI:
1046-7408(200007)44:1<9:HFDVDA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL MICROVASCULAR DENSITY; NORMAL MENSTRUAL-CYCLE; PLACENTA GROWTH-FACTOR; BETA BINDING-PROTEIN; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; RECEPTOR COMPLEX; TUBE FORMATION; ANGIOGENESIS; PREECLAMPSIA;
Keywords:
abortion; endoglin; human; pregnancy; microvascular; density; VE-cadherin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Arck, P Psychosomat Biomed Forschungszentrum, Charite, Med Klin Mit Schwerpunkt, Campus Virchow Klinikum,Augustenburger Pl 1, D-13353 Berlin, GermanyPsychosomat Biomed Forschungszentrum Campus Virchow Klinikum,Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
B. Vailhe et al., "Human first-trimester decidua vascular density: An immunohistochemical study using VE-cadherin and endoglin as endothelial cell markers", AM J REPROD, 44(1), 2000, pp. 9-15

Abstract

PROBLEM: Angiogenesis and vasculogenesis appear to be of critical importance for the success of pregnancy. Recent data have emphasized that pregnancycomplications, such as abortion or pre-eclampsia, are linked with vascularpathologies. The aim of this study was to quantify human first-trimester decidua microvascular density, using two novel, highly specific endothelial cell markers, VE-cadherin and endoglin. METHOD OF STUDY: We collected decidua from women undergoing termination ofnormal pregnancies. VE-cadherin and endoglin were localized by immunohistochemistry. The blood vessel densities detected by VE-cadherin or endoglin-stainings were microscopically quantified per mm(2). RESULTS: Endothelial cells in first-trimester human decidua both express VE-cadherin and endoglin. The microvascular density detected by VE-cadherin-staining varied from 32.2 +/- 1.7 in decidua basalis, to 30 +/- 0.6 in decidua parietalis. For the endoglin-staining, the values varied from 37.5 +/- 3 in decidua basalis, and 26.7 +/- 1.2 in decidua parietalis. CONCLUSIONS: Our data shows that both VE-cadherin and endoglin are good candidates to highlight the decidual endothelial cells, and to quantify the blood vessels density of endometrium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:13:41