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Titolo:
Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: A double-blind, placebo-controlled study
Autore:
DeBattista, C; Posener, JA; Kalehzan, BM; Schatzberg, AF;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 8, volume: 157, anno: 2000,
pagine: 1334 - 1337
SICI:
0002-953X(200008)157:8<1334:AAEOIH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PSYCHOTIC DEPRESSION; MAJOR-DEPRESSION; MOOD; DEXAMETHASONE; ILLNESS; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: DeBattista, C Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford,CA 94305 USA Stanford Univ Stanford CA USA 94305 Stanford, CA 94305 USA
Citazione:
C. DeBattista et al., "Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: A double-blind, placebo-controlled study", AM J PSYCHI, 157(8), 2000, pp. 1334-1337

Abstract

Objective: The primary objective of this investigation was to examine the acute antidepressant effects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patients with major depression. Method: Twenty-two patients who met DSM-III-R criteria for nonpsychotic major depression were randomly assigned to receive intravenously 1 mu g/kg ofovine CRH, 15 mg of hydro-cortisone, or saline under double-blind conditions on day 1. Standard depression rating scales were completed on day 1 before the study medications were administered and again the following day (day2). Results: Patients treated with hydrocortisone demonstrated a significantlygreater reduction in total 22-item Hamilton Depression Rating Scale scores(mean reduction=8.4 points or 37%) than patients given ovine CRH (mean=1.2points) or pla cebo (mean=1.3 points). Conclusions: Acute hydrocortisone infusion is associated with a rapid and robust reduction in depressive symptoms. The authors discuss the therapeutic implications of these findings.

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Documento generato il 03/12/20 alle ore 15:55:15