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Titolo:
Cutaneous spindle-cell B-cell lymphoma - A morphologic variant of cutaneous large B-cell lymphoma
Autore:
Cerroni, L; El-Shabrawi-Caelen, L; Fink-Puches, R; LeBoit, PE; Kerl, H;
Indirizzi:
Graz Univ, Dept Dermatol, A-8036 Graz, Austria Graz Univ Graz Austria A-8036 Univ, Dept Dermatol, A-8036 Graz, Austria Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA hol, San Francisco, CA USA Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF DERMATOPATHOLOGY
fascicolo: 4, volume: 22, anno: 2000,
pagine: 299 - 304
SICI:
0193-1091(200008)22:4<299:CSBL-A>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRUE HISTIOCYTIC ORIGIN; SARCOMATOID VARIANT; KI-1 LYMPHOMA; SECTIONS; ENTITY;
Keywords:
cutaneous large B-cell lymphoma; spindle-cell B-cell lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Cerroni, L Graz Univ, Dept Dermatol, Auenbruggerpl 8, A-8036 Graz, AustriaGraz Univ Auenbruggerpl 8 Graz Austria A-8036 36 Graz, Austria
Citazione:
L. Cerroni et al., "Cutaneous spindle-cell B-cell lymphoma - A morphologic variant of cutaneous large B-cell lymphoma", AM J DERMAT, 22(4), 2000, pp. 299-304

Abstract

The morphologic spectrum of large B-cell lymphoma is broad. Several unusual variants have been described such as lymphoma with myxoid stroma, sclerosing B-cell lymphoma, signet ring-cell lymphoma, and multilobated B-cell lymphoma among others. We report on five cases of cutaneous large B-cell lymphoma in which the neoplastic cells were spindle-shaped. In two cases, the clinical features fulfilled those of a primary cutaneous lymphoma; in the three other cases, the lymphoma most likely arose primarily in the skin, but incomplete clinical workups precluded definite categorization. The patients ranged in age from 30 to 89 years and presented with solitary lesions on the trunk or head. Histopathologic examination revealed nodular or dense diffuse infiltrates involving the entire dermis as well as the subcutaneous fatin some cases. Thickened collagen bundles between the spindled cells were present in one case. Cytomorphologic analysis showed the presence of round or oval medium-sized and large-sized lymphocytes with features of centrocytes and centroblasts in some foci, with others dominated by cells with spindle-shaped, elongated, twisted nuclei with dispersed chromatin and scant cytoplasm. Immunohistologic analysis revealed that both round or oval and spindled cells were positive for CD20 in all cases; in all cases tested, these cells were also positive for MIB-1 and were negative for CD3, CD5, CD43, CD45RO, CD21, CD30, CD68, S-100, HMB-45, actin, smooth-muscle actin, and cytokeratin. Bcl-2 was expressed in one of three cases tested. Analysis of the rearrangement of the J(H) gene by polymerase chain reaction performed in one case showed a monoclonal pattern. Spindle-cell large B-cell lymphoma represents a distinctive rare subtype of the cutaneous large B-cell lymphoma and can arise primarily in the skin in some cases. Recognition of this variant is necessary to avoid misdiagnosis of other cutaneous malignant spindle-cell tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 09:33:52