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Titolo:
Adenylyl cyclase activity is increased in younger, but decreased in older,alcoholic patients after detoxification
Autore:
Dahmen, N; Pauly, T; Szegedi, A; Wetzel, H; Anghelescu, I; Ferdinand, K; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
ALCOHOL AND ALCOHOLISM
fascicolo: 3, volume: 35, anno: 2000,
pagine: 249 - 254
SICI:
0735-0414(200005/06)35:3<249:ACAIII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; MESSENGER-RNA; AGE; LYMPHOCYTES; ETHANOL; CAMP; EXPRESSION; RECEPTORS; ADDICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 ermany
Citazione:
N. Dahmen et al., "Adenylyl cyclase activity is increased in younger, but decreased in older,alcoholic patients after detoxification", ALC ALCOHOL, 35(3), 2000, pp. 249-254

Abstract

Acute and chronic administration of ethanol leads to alterations of the adenylyl cyclase (AC) signal transduction pathway. This study examined whether the formation of cAMP by AC in lymphocytes correlates with age in alcoholic patients and in healthy controls. Blood was drawn for preparation of lymphocyte membranes and for determination of basal, GTP gamma S-stimulated, and forskolin-stimulated AC activity from 68 actively drinking alcoholic patients (age, mean +/- SD: 45 +/- 10; range: 26-69 years) after ethanol detoxification. The patients' AC activity correlated negatively with age. In contrast, no effect of age was observed in the healthy controls (age, mean +/-SD: 42 +/- 11; range: 24-65 years). The age-related decrease in AC activity of alcoholic patients could not be attributed to the duration of regular alcohol intake. It was partly due to the large variance of AC activity in younger and middle-aged alcoholics.

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Documento generato il 25/01/20 alle ore 09:26:43