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Titolo:
Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia
Autore:
Schuld, A; Kraus, T; Hinze-Selch, D; Haack, M; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
ACTA PSYCHIATRICA SCANDINAVICA
fascicolo: 2, volume: 102, anno: 2000,
pagine: 153 - 155
SICI:
0001-690X(200008)102:2<153:GCFPLD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS; NEUTROPENIA;
Keywords:
agranulocytosis; antipsychotic agents; cytokines; drug therapy; hematopoietic growth factors; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia", ACT PSYC SC, 102(2), 2000, pp. 153-155

Abstract

Objective: Recent case studies suggest that impaired granulopoiesis, well-known to occur during clozapine treatment, may also be observed when olanzapine is administered. The underlying mechanisms are unknown, but haematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF) are likely to be involved. Method: We measured the plasma levels of G-CSF and of other cytokines longitudinally in a female patient who developed granulocytopenia twice, first during clozapine treatment and again when olanzapine was administered. Results: G-CSF levels, but not those of other cytokines, closely paralleled granulocyte counts, yielding a significant positive correlation. G-CSF was not detectable in plasma when granulocytopenia occurred. Granulocytopeniaresolved spontaneously despite continuing treatment with olanzapine. Conclusion: The present case suggests that clozapine and olanzapine both are able to induce transient granulocytopenia through a similar or common mechanism that does not involve a compensatory increase in C-CSF levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:19:12