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Titolo:
Obstetric risks and vertical transmission of hepatitis C virus infection in pregnancy
Autore:
Hillemanns, P; Dannecker, C; Kimmig, R; Hasbargen, U;
Indirizzi:
Univ Munich, Dept Obstet & Gynecol, Munich, Germany Univ Munich Munich Germany nich, Dept Obstet & Gynecol, Munich, Germany
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 7, volume: 79, anno: 2000,
pagine: 543 - 547
SICI:
0001-6349(200007)79:7<543:ORAVTO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TO-INFANT TRANSMISSION; NATURAL-HISTORY;
Keywords:
cesarean delivery; hepatitis C virus; pregnancy; vertical transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hillemanns, P Univ Munich, Klinikum Grosshadern, Frauenklin, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich GermanyD-81377 ermany
Citazione:
P. Hillemanns et al., "Obstetric risks and vertical transmission of hepatitis C virus infection in pregnancy", ACT OBST SC, 79(7), 2000, pp. 543-547

Abstract

Background. Reports of obstetric complications of mothers infected with hepatitis C virus (HCV) are limited and the risk of mother-to-infant transmission varies widely. We assessed the course of pregnancy in HCV-infected women and the rate of vertical transmission. Methods. Between October 1992 and December 1996, 3712 pregnant patients ofthe university hospital Grosshadern Munich, Germany, were screened for anti-HCV and analyzed for HCV-RNA by polymerase chain reaction. Clinical and biochemical parameters were monitored. Children born to HCV-positive women were followed up at 6, 12 and 18 month intervals and screened for anti-HCV and HCV-RNA. Results. Thirteen (42%) of 31 anti-HCV positive patients had a cesarean section which was twice the rate of that in the HCV-negative group (p=0.004). None of the cesarean deliveries was due to complications directly caused by HCV infection. Nine (29%) of 31 anti-HCV positive women had preterm delivery compared to 19% in the anti-HCV negative patients, the difference beingstatistically not significant. Fetal outcome parameters such as APGAR score, umbilical pH and birth weight of HCV infected pregnancies were not impaired. All 29 babies tested for anti-HCV were seropositive after birth. Between 12 and 18 months of age, 10% of the infants still were anti-HCV positive, whereas only one baby was HCV-RNA positive beyond 12 months yielding a vertical transmission rate of 5% among HCV-RNA positive mothers. Conclusion. Anti-HCV positive pregnancies have an increased risk of cesarean delivery, probably due to the high-risk collective of anti-HCV positive mothers. The mother-to-child transmission rate is low and linked to maternal HCV-RNA positivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:31:37