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Titolo: DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES
Autore: TAMURA SY; SEMPLE JE; REINER JE; GOLDMAN EA; BRUNCK TK; LIMWILBY MS; CARPENTER SH; ROTE WE; OLDESHULTE GL; RICHARD BM; NUTT RF; RIPKA WC;
- Indirizzi:
- CORVAS INT INC,DEPT MED CHEM,3030 SCI PK RD SAN DIEGO CA 92121
- Titolo Testata:
- Bioorganic & medicinal chemistry letters
fascicolo: 12,
volume: 7,
anno: 1997,
pagine: 1543 - 1548
- SICI:
- 0960-894X(1997)7:12<1543:DASOAN>2.0.ZU;2-2
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HUMAN-LEUKOCYTE ELASTASE; PRO-ARG-H; NONPEPTIDIC INHIBITORS; TRIFLUOROMETHYL KETONES; SERIES; PROFILE; ACIDS;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 33
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- S.Y. Tamura et al., "DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES", Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1543-1548
Abstract
Several potent and selective inhibitors of thrombin incorporating novel heterocyclic peptide surrogates in the P-3-P-2 position of peptidylargininals have been discovered. Illustrated in this article are three classes of heterocycles: pyridones, uracils, and pyrimidinones. The synthesis and biological activities of these unique aromatic heterocyclic derivatives are reported herein. (C) 1997 Elsevier Science Ltd.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:56:11