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Titolo:
Differentiating large cell lymphoma from indolent small B-cell lymphoma infine needle aspirates using p53, PCNA and transformed lymphocyte count
Autore:
Young, NA; Ehya, H; Klein-Szanto, A; Litwin, S; Smith, MR; Al-Saleem, T;
Indirizzi:
Fox Chase Canc Ctr, Dept Pathol, Outpatient Lab, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Biostat, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Pathol, Cytopathol Lab, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
ACTA CYTOLOGICA
fascicolo: 4, volume: 44, anno: 2000,
pagine: 592 - 603
SICI:
0001-5547(200007/08)44:4<592:DLCLFI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; FOLLICULAR LYMPHOMAS; NUCLEAR ANTIGEN; TUMOR PATHOLOGY; FLOW-CYTOMETRY; CYCLIN PCNA; DIAGNOSIS; PROLIFERATION; CYTOLOGY; PROTEIN;
Keywords:
lymphoma; large-cell; B-cell lymphoma; aspiration biopsy; lymphocyte count; p53 protein; proliferating cell nuclear antigen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Young, NA Fox Chase Canc Ctr, Dept Pathol, Outpatient Lab, 7701 Burholme Ave, Philadelphia, PA 19111 USA Fox Chase Canc Ctr 7701 Burholme Ave Philadelphia PA USA 19111 A
Citazione:
N.A. Young et al., "Differentiating large cell lymphoma from indolent small B-cell lymphoma infine needle aspirates using p53, PCNA and transformed lymphocyte count", ACT CYTOL, 44(4), 2000, pp. 592-603

Abstract

OBJECTIVE: To determine the usefulness of proliferating cell nuclear antigen (PCNA), p53 protein expression and transformed lymphocyte count (TLC) asadjunctive rests to differentiate indolent small B-cell lymphoma from large cell lymphoma in fine needle aspiration biopsies. STUDY DESIGN: Aspirates of lymphoproliferative disorders from April 1993 to January i997 were reviewed. The percentage of TLCs tons determined all the Papanicolaou smear. The percentage and intensify of p53 and PCNA il immunocytochemical staining was evaluated on cell block sections. These results were compared and correlated with the final diagnoses based on available morphology, flow cytometry and clinical history. RESULTS: There were 40 cases of non-Hodgkin's lymphoma and 12 reactive lymph nodes. Adequate cell blacks were available oil 16 large cell lymphomas, 7 grade 1-2 follicular center cell lymphomas, 6 mucosal associated lymphoidtissue lymphomas, 2 small lymphocytic lymphomas and 2 mantle cell lymphomas. Average TLC and p53 nuclear staining was highest in large cell lymphomas(57% TLC and 24% p53), followed by grades I and 2 follicular lymphomas (14% TLC and 15% p53) and lowest in other indolent lymphomas (<10% TLC and <1%p53). Average PCNA staining was highest in large cell lymphomas (46%) and lowest in small lymphocytic lymphomas (7%); however, TLC was the best parameter for differentiating large cell lymphoma from indolent small B-cell lymphoma. CONCLUSION: TLC differentiated large cell lymphoma fi om indolent small B-cell lymphoma better than either p53 or PCNA alone or in combination. Significant overlap between categories limits usefulness of these immunocytochemical stains for differentiating these entities.

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Documento generato il 01/12/20 alle ore 01:13:02