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Titolo:
Morphological changes in the kidney of dogs chronically exposed to exogenous growth hormone
Autore:
Molon-Noblot, S; Laroque, P; Prahalada, S; Stabinski, LG; Peter, CP; Duprat, P; van Zwieten, MJ;
Indirizzi:
Merck Sharp & Dohme Chibret Labs, Res Ctr, Dept Safety Assessment, F-63203Riom, France Merck Sharp & Dohme Chibret Labs Riom France F-63203 F-63203Riom, France
Titolo Testata:
TOXICOLOGIC PATHOLOGY
fascicolo: 4, volume: 28, anno: 2000,
pagine: 510 - 517
SICI:
0192-6233(200007/08)28:4<510:MCITKO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION-RATE; TUBULAR BASOLATERAL MEMBRANES; FACTOR-I; EXTRACELLULAR-MATRIX; TRANSGENIC MICE; GENE-EXPRESSION; RENAL HYPERTROPHY; FUSION GENES; INSULIN; GLOMERULOSCLEROSIS;
Keywords:
kidney; growth hormone; pharmacological effect; morphometry; electron microscopy; insulin-like growth factor-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Prahalada, S Merck Res Labs, Safety Assessment, WP45-232, W Point, PA 19486 USA Merck Res Labs WP45-232 W Point PA USA 19486 nt, PA 19486 USA
Citazione:
S. Molon-Noblot et al., "Morphological changes in the kidney of dogs chronically exposed to exogenous growth hormone", TOX PATHOL, 28(4), 2000, pp. 510-517

Abstract

Porcine growth hormone was administered subcutaneously to beagle dogs at doses of 0.025, 0.1, and 1 IU/kg/d for 14 weeks, markedly elevating serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. This wasaccompanied by a significant increase in body weight gain and kidney weights in both male and female dogs. The increase in kidney weight (6 to 54%) was slightly greater than the increase in body weight (6 to 40%). By light microscopy, glomerular deposits, mesangial thickening, and very slight cellular infiltration in glomeruli were seen in mid- and high-dose groups. Basedon morphometric evaluation, there was an increase in the renal glomerular area, which was statistically significant (p less than or equal to 0.05) inthe mid- and high-dose males and in the high-dose females. This was associated with a statistically significant (p less than or equal to 0.05) increase in the number of total glomerular cells in the mid- and high-dose males. By transmission electron microscopy, thickening of the glomerular basal lamina and diffuse increase of the mesangial matrix were observed in both male and female dogs in the mid- and high-dose groups. Immunohistochemical reactions were negative for IgG, IgM, and C3. The morphological changes in thekidney of dogs resemble the diffuse glomerulosclerosis described in human diabetic nephropathy.

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Documento generato il 07/08/20 alle ore 06:42:30