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Titolo:
Chronic-intermittent hypoxia: a model of sympathetic activation in the rat
Autore:
Sica, AL; Greenberg, HE; Ruggiero, DA; Scharf, SM;
Indirizzi:
Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Med, Div Pulm & Crit Care, New Hyde Park, NY 11040 USA Albert Einstein Coll Med New Hyde Park NY USA 11040 de Park, NY 11040 USA Columbia Univ, Coll Phys & Surg, Dept Psychiat & Anat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ychiat & Anat, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Cell Biol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ept Cell Biol, New York, NY 10032 USA Neurol Res Inst Lubec, Lubec, ME 04652 USA Neurol Res Inst Lubec Lubec MEUSA 04652 Inst Lubec, Lubec, ME 04652 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 2-3, volume: 121, anno: 2000,
pagine: 173 - 184
SICI:
0034-5687(200007)121:2-3<173:CHAMOS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE SLEEP-APNEA; ROSTRAL VENTROLATERAL MEDULLA; MEDIAL PREFRONTAL CORTEX; IBOTENIC ACID LESIONS; NUCLEUS-TRACTUS-SOLITARIUS; BLOOD-PRESSURE ELEVATION; CHRONIC EPISODIC HYPOXIA; MIDDLE CEREBRAL-ARTERY; C1 ADRENALINE NEURONS; INSULAR CORTEX;
Keywords:
blood pressure, systemic hypertension, hypoxia; brainstem, sympathetic nervous system; hypoxia, chronic-intermittent, hypertension; hypertension, systemic, chronic-intermittent hypoxia, sleep apnea; sleep, apnea, hypertension; sympathetic nervous system, hypoxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Sica, AL Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Med, Div Pulm & Crit Care, Room C-20,Long Isl Campus, New Hyde Park, NY 11040 USA Albert Einstein Coll Med Room C-20,Long Isl Campus New Hyde Park NY USA 11040
Citazione:
A.L. Sica et al., "Chronic-intermittent hypoxia: a model of sympathetic activation in the rat", RESP PHYSL, 121(2-3), 2000, pp. 173-184

Abstract

This review focuses upon the development of a small animal model that incorporates exposure to chronic-intermittent hypoxia to produce systemic hypertension similar to that experienced by humans with the obstructive sleep apnea syndrome. It has been suggested that experimentally-induced hypertension, like human hypertension, is due to activation of the sympathetic nervoussystem. That hypothesis is supported by physiological studies carried out in humans with obstructive sleep apnea as well as in animals exposed to chronic-intermittent hypoxia. Furthermore, recent anatomical studies of exposed animals strongly suggested that activation was widespread and included cortical and brainstem components of the sympathetic system. Such findings, while illustrating the complexity of modeling human disease in animals, alsodemonstrate the heuristic value of chronic-intermittent hypoxia as an experimental approach. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:54:55