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Titolo:
Mixed attentional and executive deficits in medial frontal cortex lesionedrats
Autore:
Passetti, F; Humby, T; Everitt, BJ; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
PSYCHOBIOLOGY
fascicolo: 2, volume: 28, anno: 2000,
pagine: 261 - 271
SICI:
0889-6313(200006)28:2<261:MAAEDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; STRIATAL DOPAMINE DEPLETION; PREFRONTAL CORTEX; SUSTAINED ATTENTION; RESPONSE SELECTION; LOBE LESIONS; PERFORMANCE; DORSAL; MEMORY; TASK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Passetti, F Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB , England
Citazione:
F. Passetti et al., "Mixed attentional and executive deficits in medial frontal cortex lesionedrats", PSYCHOBIOLO, 28(2), 2000, pp. 261-271

Abstract

Two groups of rats were trained to detect brief, unpredictable visual stimuli in attentional paradigms with different response selection requirements. Animals had to hold their heads in a central location for a variable delay and then respond to either the same (same condition) side as or the opposite (opposite condition) side to where the visual stimulus had occurred. Following bilateral excitotoxic lesions of the medial prefrontal cortex (mPFC), rats in the same condition were impaired relative to controls, as revealed by reductions in choice accuracy and speed of responding. In the opposite condition, mPFC-lesioned animals performed at chance and were faster thancontrols to respond to the target. These results extend previous findings of accuracy deficit in mPFC-lesioned rats in a five-choice serial reaction time task in which the animals are not required to respond to targets from a fixed position. In addition, the finding of a larger deficit in the opposite condition suggests a more prominent role for the mPFC in the selection of difficult, "incompatible" responses relative to easy, "compatible" ones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:35:04