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Titolo:
Functional dissociation between dorsal and ventral regions of the medial prefrontal cortex in rats
Autore:
Gisquet-Verrier, P; Winocur, G; Delatour, B;
Indirizzi:
Univ Paris Sud, CNRS UMR 8620, Lab Neurobiol Apprentissage Memoire & Commun, F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 oire & Commun, F-91405 Orsay, France Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada
Titolo Testata:
PSYCHOBIOLOGY
fascicolo: 2, volume: 28, anno: 2000,
pagine: 248 - 260
SICI:
0889-6313(200006)28:2<248:FDBDAV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIODORSAL THALAMIC NUCLEUS; PRELIMBIC-INFRALIMBIC AREAS; FRONTAL-CORTEX; DELAYED ALTERNATION; ANTERIOR CINGULATE; TOPOGRAPHICAL ORGANIZATION; BEHAVIORAL FLEXIBILITY; AFFERENT CONNECTIONS; ELECTROLYTIC LESIONS; SEQUENTIAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Gisquet-Verrier, P Univ Paris Sud, CNRS UMR 8620, Lab Neurobiol Apprentissage Memoire & Commun, Bat 446, F-91405 Orsay, France Univ Paris Sud Bat 446Orsay France F-91405 ay, France
Citazione:
P. Gisquet-Verrier et al., "Functional dissociation between dorsal and ventral regions of the medial prefrontal cortex in rats", PSYCHOBIOLO, 28(2), 2000, pp. 248-260

Abstract

In order to investigate the respective roles of dorsal and ventral parts of the medial prefrontal cortex (mPFC) on a delayed alternation task, the acquisition of which is disrupted by large mPFC lesions (Winocur, 1991), ratswith circumscribed lesions to the anterior cingulate (ACd) or the prelimbic-infralimbic (PL-IL) cortex were compared. As was predicted, ACd lesions severely impaired performance, and an analysis of the results suggests an involvement of this region in sequencing temporally ordered behavior. On the other hand, PL-IL lesions had no effect, a finding that was in contrast with previous evidence that PL-IL lesions induced delay-dependent deficits on a similar task (Delatour & Gisquet-Verrier, 1999). However, an important difference between the tasks related to the scheduling of critical delays. Whereas in the previous experiment, delay intervals were increased progressively in a block design, variable intertrial intervals were a constant feature of training in the present Experiment 1. In Experiment 2, rats with PL-ILlesions were administered Delatour and Gisquet-Verrier's (1999) alternation task, but modified to incorporate Winocur's (1991) variable-interval procedure that required less response adjustment. Under these conditions, the PL-IL group performed normally, as in Experiment 1. Taken together, the results provide evidence that the PL-IL cortex is implicated in processes that support attentional mechanisms and behavioral flexibility. Overall, the present results support the general hypothesis of subregionalization of mPFC functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:41:01