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Titolo:
Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study
Autore:
Stein, MB; Norton, GR; Walker, JR; Chartier, MJ; Graham, R;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Manitoba, Dept Psychiat, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 at, Winnipeg, MB R3T 2N2, Canada Univ Manitoba, Dept Psychol, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 ol, Winnipeg, MB R3T 2N2, Canada Univ Manitoba, Dept Clin Hlth Psychol, Winnipeg, MB, Canada Univ ManitobaWinnipeg MB Canada Clin Hlth Psychol, Winnipeg, MB, Canada
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 3, volume: 94, anno: 2000,
pagine: 191 - 200
SICI:
0165-1781(20000717)94:3<191:DSSRIE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; DOUBLE-BLIND; MULTICENTER TRIAL; PLACEBO; SERTRALINE; AGORAPHOBIA; PAROXETINE; RELAXATION; ANXIETY;
Keywords:
agoraphobia; panic attacks; selective serotonin re-uptake inhibitor; paroxetine; psychotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, MB Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
M.B. Stein et al., "Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study", PSYCHIAT R, 94(3), 2000, pp. 191-200

Abstract

Selective serotonin re-uptake inhibitors (SSRIs) and cognitive behavioral therapies (CBTs) are both considered as first-line treatments for panic disorder, but the advantages of a combined therapy have yet to be definitivelydemonstrated. We evaluated in this pilot study the effects of combining SSRIs (vs. a placebo) with a very brief form of cognitive-behavioral. therapyprovided to all participants. Thirty-three subjects with DSM-IV panic disorder, with or without agoraphobia, were randomized to receive either paroxetine or a placebo with flexible dosing (10-50 mg/day). Medication visits were brief (15 min), infrequent (6 in total) and non-directive. An expert cognitive-behavior therapist administered one initial 45-min session and one subsequent 30-min session of very brief CBT (vbCBT) at weeks 5 and 7, respectively. Sessions were supplemented with educational and directive reading materials. Patients in both groups (i.e. vbCBT + paroxetine; vbCBT + placebo) improved similarly and substantially on most measures during the 10 weeksof acute treatment. At week 10, the proportion of panic-free patients was significantly higher in the paroxetine-treated group than in the placebo group (80 vs. 25%; P < 0.007), as was the proportion of subjects who rated themselves as 'very much improved' at week 10 (60 vs. 13%; P < 0.017). These findings point to the need for additional studies to confirm the effectiveness of very brief forms of CBT, and to document the circumstances in which combined treatment with an SSRI would be warranted. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 05/04/20 alle ore 23:10:35