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Titolo:
Mecamylamine blockade of both positive and negative effects of IV nicotinein human volunteers
Autore:
Lundahl, LH; Henningfield, JE; Lukas, SE;
Indirizzi:
Harvard Univ, Sch Med, McLean Hosp, Behav Psychopharmacol Res Lab, Belmont, MA 02478 USA Harvard Univ Belmont MA USA 02478 harmacol Res Lab, Belmont, MA 02478 USA Pinney Associates, Bethesda, MD 20814 USA Pinney Associates Bethesda MD USA 20814 ssociates, Bethesda, MD 20814 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 66, anno: 2000,
pagine: 637 - 643
SICI:
0091-3057(200007)66:3<637:MBOBPA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS NICOTINE; SMOKING CESSATION; CIGARETTE-SMOKING; ANTAGONISTS;
Keywords:
nicotine; mecamylamine; craving; tobacco; human subjects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lukas, SE Harvard Univ, Sch Med, McLean Hosp, Behav Psychopharmacol Res Lab, East House 3,115 Mill St, Belmont, MA 02478 USA Harvard Univ East House 3,115 Mill St Belmont MA USA 02478 8 USA
Citazione:
L.H. Lundahl et al., "Mecamylamine blockade of both positive and negative effects of IV nicotinein human volunteers", PHARM BIO B, 66(3), 2000, pp. 637-643

Abstract

The ganglionic blocker mecamylamine blocks the positive reinforcing effects of IV nicotine, but has been shown to increase cigarette smoking behaviorunder some conditions. The effects of mecamylamine on subjective and physiologic responses to IV nicotine were evaluated in seven healthy male volunteer cigarette smokers who provided informed consent and resided on a clinical pharmacology research unit. On four separate days, each subject was given a different oral dose of mecamylamine (placebo, 5, 10, or 20 mg). One hour later subjects received the first of four doses of IV nicotine (placebo, 0.75, 1.5, and 3.0 mg); the remaining injections were given at l-h intervals. Both the positive effects following 0.75 mg and negative effects following 3.0 mg of nicotine were significantly reversed by mecamylamine. Thus, the mecamylamine-induced increase in smoking may be due both to competitive blockade of nicotinic receptors and nicotine's reversal of aversive effects. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:56:28