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Titolo:
Effect of the dopamine D-1/5 antagonist SCH 23390 on the acquisition of conditioned fear
Autore:
Inoue, T; Izumi, T; Maki, Y; Muraki, I; Koyama, T;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 66, anno: 2000,
pagine: 573 - 578
SICI:
0091-3057(200007)66:3<573:EOTDDA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; POTENTIATED STARTLE; PREFRONTAL CORTEX; FREEZING BEHAVIOR; ACTIVATION; STRESS; RATS; SCH-23390; NEUROLEPTICS; CLOZAPINE;
Keywords:
dopamine; D-1/5 receptor; anxiety; conditioned fear;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ North 15,West 7 Sapporo Hokkaido Japan 0608638 apan
Citazione:
T. Inoue et al., "Effect of the dopamine D-1/5 antagonist SCH 23390 on the acquisition of conditioned fear", PHARM BIO B, 66(3), 2000, pp. 573-578

Abstract

The authors previously reported that typical and atypical antipsychotic drugs inhibited the acquisition but not expression of conditioned fear. The present study examined the effects of the selective dopamine D-1/5 agonist (SKF 38393) and antagonist (SCH 23390) on the acquisition and expression of conditioned fear. Drugs were administered subcutaneously to male Sprague-Dawley rats 30 min before foot shock (2.5 mA for 5 min). Twenty-four hours after foot shock, rats were again placed and observed in the shock chamber without shocks (conditioned fear). Freezing behavior induced by conditioned fear, an index of anxiety or fear, was recorded using a time-sampling procedure. SCH 23390 (0.1-1 mg/kg) inhibited the acquisition of conditioned freezing. The administration of SCH 23390 at a dose of 0.1 mg/kg 30 min after foot shock did not affect conditioned freezing. Taken together. it is concluded that D-1/5 antagonism inhibits the acquisition of conditioned fear. SKF 38393 (3-20 mg/kg) failed to change the acquisition of conditioned fear. SCH 23390 or SKF 38393 administered prior to testing did not reduce the expression of conditioned fear. These results suggest that D-1/5, receptors may play a role in the development of fear or anxiety. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:01:08