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Titolo:
The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm
Autore:
Turgeon, SM; Auerbach, EA; Duncan-Smith, MK; George, JR; Graves, WW;
Indirizzi:
Amherst Coll, Dept Psychol, Amherst, MA 01002 USA Amherst Coll Amherst MAUSA 01002 ll, Dept Psychol, Amherst, MA 01002 USA Amherst Coll, Neurosci Program, Amherst, MA 01002 USA Amherst Coll Amherst MA USA 01002 Neurosci Program, Amherst, MA 01002 USA Hampshire Coll, Dept Nat Sci, Amherst, MA 01002 USA Hampshire Coll Amherst MA USA 01002 , Dept Nat Sci, Amherst, MA 01002 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 66, anno: 2000,
pagine: 533 - 539
SICI:
0091-3057(200007)66:3<533:TDEODA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGMA-RECEPTOR LIGAND; SCHIZOPHRENIC ATTENTION DISORDER; BINDING-SITES; ANTIPSYCHOTIC-DRUGS; CHRONIC AMPHETAMINE; LOCOMOTOR-ACTIVITY; GUINEA-PIG; NIGROSTRIATAL DOPAMINE; EXTRACELLULAR DOPAMINE; FUNCTIONAL INTERACTION;
Keywords:
latent inhibition; sigma receptors; NMDA receptors; phencyclidine; schizophrenia; DTG; MK-801;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Turgeon, SM Amherst Coll, Dept Psychol, POB 5000,Campus Box 2236, Amherst,MA 01002 USA Amherst Coll POB 5000,Campus Box 2236 Amherst MA USA 01002 USA
Citazione:
S.M. Turgeon et al., "The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm", PHARM BIO B, 66(3), 2000, pp. 533-539

Abstract

The delayed effects of phencyclidine (PCP) have been shown to disrupt latent inhibition (LI) in a conditioned taste-aversion paradigm. In an attempt to understand the mechanism of this disruption. the delayed effects of the:selective sigma receptor agonist 1,3-Di(2-tolyl)guanidine (DTG) and the selective NMDA receptor antagonist MK-801 on latent inhibition were assessed in the same paradigm. Water-deprived male rats were allowed access to either water (non-preexposed; NPE) or 5% sucrose (preexposed; PE) for 30 min on 2 consecutive days. On the third day, animals were allowed access to sucrose and subsequently injected with lithium chloride. On the forth day, animals were allowed access to both sucrose and water. LI was assessed by comparing the percent sucrose consumed in PE and NPE groups on the fourth day. DTG(1.0, 5.0, or 10.0 mg/kg), MK-801 (0.5, 1.0, or 2.0 mg/kg), or vehicle wasadministered IP 20 h before preexposure (days 1 and 2) and conditioning (day 3). In vehicle-treated groups. PE animals consumed a significantly higher percent sucrose on the test day than NPE animals, indicating the presenceof LI. DTG (10.0 mg/kg) and MK-801 (2.0 mg/kg) decreased the percent sucrose consumed by animals in the PE group to the level observed in the NPE group, indicating disrupted LI. However: this dose of MK-801 was found to produce a decrease in percent sucrose consumed in PE animals not treated with lithium chloride, indicating that the decrease observed in the LI paradigm could be due to MK-801-induced decrease in taste preference for sucrose rather than a disruption of LI. Lower doses of MK-801 that did not produce a decrease in taste preference fbr sucrose did not significantly disrupt LI. None of the doses of DTG tested altered taste preference for sucrose. These data suggest a role for sigma receptors in the previously observed PCP-induced disruption of LI. Published by Elsevier Science Inc.. 2000.

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Documento generato il 22/01/20 alle ore 12:19:24