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Titolo:
Newly synthesized dopamine in the nucleus accumbens is regulated by beta-adrenergic, but not alpha-adrenergic, receptors
Autore:
Tuinstra, T; Cools, AR;
Indirizzi:
Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, NetherlandsUniv Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 98, anno: 2000,
pagine: 743 - 747
SICI:
0306-4522(2000)98:4<743:NSDITN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW RESPONDERS; RAT STRIATUM; CYCLIC-AMP; MICRODIALYSIS; RELEASE; TERMINALS; MECHANISM; BEHAVIOR; NOVELTY; INVIVO;
Keywords:
alpha-methyl-p-tyrosine; noradrenaline; individual differences; microdialysis; reserpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tuinstra, T Univ Nijmegen, Dept Psychoneuropharmacol, POB 9101, NL-6500 HBNijmegen, Netherlands Univ Nijmegen POB 9101 Nijmegen Netherlands NL-6500HB rlands
Citazione:
T. Tuinstra e A.R. Cools, "Newly synthesized dopamine in the nucleus accumbens is regulated by beta-adrenergic, but not alpha-adrenergic, receptors", NEUROSCIENC, 98(4), 2000, pp. 743-747

Abstract

Previous microdialysis studies have led to the hypothesis that activation of mesolimbic alpha-adrenoceptors inhibits the release of mesolimbic dopamine from alpha-methyl-p-tyrosine-resistant, reserpine-sensitive pools, and that activation of mesolimbic beta-adrenoceptors stimulates the release of mesolimbic dopamine from alpha-methyl-p-tyrosine-sensitive, reserpine-resistant pools. In the present study we analysed the ability of mesolimbic alpha- and beta-adrenoceptors to modulate the release of dopamine from alpha-methyl-p-tyrosine-sensitive pools in the nucleus accumbens of high and low responders to novelty. Under non-challenged conditions, alpha-methyl-p-tyrosine (10(-4) M, 40 min) produced a decrease in dopamine release that did not differ between high and low responders to novelty. The continuous infusion of 10(-6) M isoproterenol (beta-adrenoceptor agonist) diminished the alpha-methyl-p-tyrosine-induced decrease in dopamine, whereas the continuous infusion of 10(-5) M phenylephrine (alpha-adrenoceptor agonist) remained ineffective. It is concluded that the release of mesolimbic dopamine from alpha-methyl-p-tyrosine-sensitive, reserpine-resistant pools is under excitatory controlof beta-adrenergic, but not alpha-adrenergic, receptors in both high and low responders to novelty. In general, this study implies that mesolimbic dopamine that is derived from different pools is regulated via different noradrenergic receptors. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:44:14