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Titolo:
Cerebral regions associated with verbal response initiation, suppression and strategy use
Autore:
de Zubicaray, GI; Zelaya, FO; Andrew, C; Williams, SCR; Bullmore, ET;
Indirizzi:
Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England Inst Psychiat, Dept Biostat, London, England Inst Psychiat London England st Psychiat, Dept Biostat, London, England Inst Psychiat, Dept Comp, London, England Inst Psychiat London EnglandInst Psychiat, Dept Comp, London, England
Titolo Testata:
NEUROPSYCHOLOGIA
fascicolo: 9, volume: 38, anno: 2000,
pagine: 1292 - 1304
SICI:
0028-3932(2000)38:9<1292:CRAWVR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR PREFRONTAL CORTEX; FRONTAL-LOBE LESIONS; GENERIC BRAIN ACTIVATION; FUNCTIONAL-ANATOMY; WORKING-MEMORY; STROOP TASK; SELECTIVE ATTENTION; IMAGE-ANALYSIS; RETRIEVAL; INTERFERENCE;
Keywords:
functional MRI; verbal response initiation; response suppression; inhibition; strategy use; prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
G.I. de Zubicaray et al., "Cerebral regions associated with verbal response initiation, suppression and strategy use", NEUROPSYCHO, 38(9), 2000, pp. 1292-1304

Abstract

Cerebral activation associated with performance on a novel task involving two conditions was investigated with functional magnetic resonance imaging (fMRI), In the response initiation condition, subjects nominated the general subordinate category to which each of a series of exemplars (concrete nouns) belonged. In the response suppression condition, subjects were requiredto nominate a general superordinate category Co which each exemplar did not belong, with the instruction that they a ere not to nominate the same category response twice in a row. Both conditions produced distinct patterns of activation relative to an articulation control condition employing identical stimuli. When initiation and suppression conditions were directly compared, response suppression produced activation in the right frontal pole, orbital frontal cortex and anterior cingulate, left dorsolateral prefrontal cortex and posterior cingulate, and bilaterally in the precuneus, visual association cortex and cerebellum Response latencies were significantly longerin the suppression condition. Two broadly-defined strategies associated with the comet production of words during the suppression condition were a self-ordered selection from among the superordinate categories identified during the first section of the task and the generation of novel category responses. The neuroanatomical correlates of response initiation, suppression and strategy use are discussed, as are the respective roles of response suppression and strategy generation. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:13:18