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Titolo:
Evidence that alpha-MSH induced grooming is not primarily mediated by any of the cloned melanocortin receptors
Autore:
Sanchez, MS; Celis, ME; Schioth, HB;
Indirizzi:
Uppsala Univ, Dept Neurosci, Biomed Ctr, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 Biomed Ctr, S-75124 Uppsala, Sweden Natl Univ Cordoba, Fac Ciencias Quim, Dept Farmacol, Lab Fisiol, RA-5016 Cordoba, Argentina Natl Univ Cordoba Cordoba Argentina RA-5016 , RA-5016 Cordoba, Argentina Melacure Therapeut AB, Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden cure Therapeut AB, Uppsala, Sweden
Titolo Testata:
NEUROPEPTIDES
fascicolo: 2, volume: 34, anno: 2000,
pagine: 77 - 82
SICI:
0143-4179(200004)34:2<77:ETAIGI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; GAMMA-MSH; RADIOLIGAND BINDING; SEXUAL-BEHAVIOR; BETA-ENDORPHIN; ACTH RECEPTOR; PEPTIDES; ANTAGONISTS; BRAIN; MELANOTROPIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schioth, HB Uppsala Univ, Dept Neurosci, Biomed Ctr, Box 593, S-75124 Uppsala, Sweden Uppsala Univ Box 593 Uppsala Sweden S-75124 4 Uppsala, Sweden
Citazione:
M.S. Sanchez et al., "Evidence that alpha-MSH induced grooming is not primarily mediated by any of the cloned melanocortin receptors", NEUROPEPTID, 34(2), 2000, pp. 77-82

Abstract

It is well established that melanocortic peptides, such as melanocyte-stimulating hormone (MSH) and adrenocorticotropin, induce grooming behavior. The MC3 and MC4 receptors are the MC receptors which are most abundantly expressed in the brain. gamma-MSH, a peptide with preference to the MC3 receptor, however, does not induce grooming. Recent studies have shown that MC4 receptor antagonists are very effective in inhibiting alpha-MSH induced grooming. These data have indicated that grooming behavior in rodents may be mediated by the MC4 receptor. In this study we investigated if the recently developed MC1 receptor selective agonist MS05 was able to induce grooming in comparison with alpha-MSH. The results show that MS05 is effective in inducing grooming after either intracerebroventricular or ventral tegmental areaadministration in rats. Central administration of either MS05 or alpha-MSHbesides grooming also induced stretching, yawning, rearing and locomotion. The results indicate that the earlier hypothesis that the MC4 receptor is the main mediator of grooming behavior has to be modified. Moreover, as this behaviour does not pharmacologically correlate to the profile of any of the five cloned MC receptors, we suggest that alpha-MSH induced grooming maynot primarily be mediated by any of these receptors. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:55:19