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Titolo:
Determination of the lipophilicity of some carbonyl derivatives of 2-aminoimidazolines-2 by reversed-phase thin-layer chromatography. part 2. The lipophilicity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines and 1-aryl-5,6(1H) dioxo-2,3-dihydroimidazo[1,2-a] imidazoles
Autore:
Matosiuk, D; Jozwiak, K;
Indirizzi:
Med Univ, Fac Pharm, Dept Synth & Technol Drugs, PL-20081 Lublin, Poland Med Univ Lublin Poland PL-20081 & Technol Drugs, PL-20081 Lublin, Poland Med Univ, Fac Pharm, Dept Inorgan & Analyt Chem, PL-20081 Lublin, Poland Med Univ Lublin Poland PL-20081 n & Analyt Chem, PL-20081 Lublin, Poland
Titolo Testata:
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
fascicolo: 2, volume: 13, anno: 2000,
pagine: 130 - 134
SICI:
0933-4173(200003/04)13:2<130:DOTLOS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHARACTER; VALUES; RM;
Keywords:
RPTLC; lipophilicity; 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines; 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo[1,2-a]imidazoles; carbonyl derivatives of 2-aminoimidazolines-2; partition coefficient, log P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Matosiuk, D Med Univ, Fac Pharm, Dept Synth & Technol Drugs, Staszica 6, PL-20081 Lublin, Poland Med Univ Staszica 6 Lublin Poland PL-20081 081 Lublin, Poland
Citazione:
D. Matosiuk e K. Jozwiak, "Determination of the lipophilicity of some carbonyl derivatives of 2-aminoimidazolines-2 by reversed-phase thin-layer chromatography. part 2. The lipophilicity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines and 1-aryl-5,6(1H) dioxo-2,3-dihydroimidazo[1,2-a] imidazoles", J PL CHROM, 13(2), 2000, pp. 130-134

Abstract

The lipophilicity of twenty five new carbonyl derivatives of 1-aryl-2-aminoimidazolines-2 (twenty 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a] [1,3,5]triazines and five 1-aryl-5,6(1H)dioxo-2,3- dihydroimidazo[1,2-a] imidazoles) has been determined by RPTLC on commercial RP-18 silica gel plateswith methanol-acetic acid-water as mobile phase. R-M values for all the com pounds mere linearly dependent on mobile phase methanol concentration within the range 60 to 90%. Experimental lipophilicity was determined by use of the calibration curve obtained for six standards and partition coefficients (as logP) of all the compounds were calculated by means of two differentsoftware packages ChemPlus (Hyper-Chem) and SciLogP (Alchemy 2000). The values calculated with the SciLogP package correlated very well (r > 0.95) with the log P-TLC values; correlation was good (r > 0.8) for values calculated by use of the ChemPlus package. This suggests that both methodologies are suitable for calculation of the lipophilicity of dioxo derivatives of 2-aminoimidazoline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:20:28