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Titolo:
The retention behavior of several semisynthetic cephalosporins in planar chromatography
Autore:
Eric, S; Agbaba, D; Vladimirov, S; Zivanov-Stakic, D;
Indirizzi:
Fac Pharm, Dept Pharmaceut Chem, YU-11000 Belgrade, Yugoslavia Fac Pharm Belgrade Yugoslavia YU-11000 em, YU-11000 Belgrade, Yugoslavia
Titolo Testata:
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
fascicolo: 2, volume: 13, anno: 2000,
pagine: 88 - 92
SICI:
0933-4173(200003/04)13:2<88:TRBOSS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-ZONE-ELECTROPHORESIS; QUANTITATIVE-DETERMINATION; TLC PLATES; CEFEPIME; PLASMA;
Keywords:
hydrophobicity (R-M((o)under-bar), m and C-o); lipophilicity (log P); mechanism of adsorption; quantitative structure-activity relationships (QSAR); cephalosporins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Agbaba, D Fac Pharm, Dept Pharmaceut Chem, Vojvode Stepe 450,POB 146, YU-11000 Belgrade, Yugoslavia Fac Pharm Vojvode Stepe 450,POB 146 Belgrade Yugoslavia YU-11000
Citazione:
S. Eric et al., "The retention behavior of several semisynthetic cephalosporins in planar chromatography", J PL CHROM, 13(2), 2000, pp. 88-92

Abstract

The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 10:18:04