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Titolo:
Attenuated modified vaccinia virus Ankara can be used as an immunizing agent under conditions of preexisting immunity to the vector
Autore:
Ramirez, JC; Gherardi, MM; Rodriguez, D; Esteban, M;
Indirizzi:
CSIC, Ctr Nacl Biotecnol, Dept Mol & Cellular Biol, E-28049 Madrid, Spain CSIC Madrid Spain E-28049 ept Mol & Cellular Biol, E-28049 Madrid, Spain
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 16, volume: 74, anno: 2000,
pagine: 7651 - 7655
SICI:
0022-538X(200008)74:16<7651:AMVVAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETICALLY-ENGINEERED POXVIRUSES; EXPRESSING HIV ENVELOPE; TYPE-1 GLYCOPROTEIN-D; CLASS-I; IMMUNIZATION; VACCINATION; RECOMBINANTS; INHIBITION; RESPONSES; HERPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Esteban, M CSIC, Ctr Nacl Biotecnol, Dept Mol & Cellular Biol, Campus Cantoblanco, E-28049 Madrid, Spain CSIC Campus Cantoblanco Madrid Spain E-28049 049 Madrid, Spain
Citazione:
J.C. Ramirez et al., "Attenuated modified vaccinia virus Ankara can be used as an immunizing agent under conditions of preexisting immunity to the vector", J VIROLOGY, 74(16), 2000, pp. 7651-7655

Abstract

A problem associated with the use of vaccinia virus recombinants as vaccines is the existence of a large human population with preexisting immunity to the vector. Here we showed that after a booster with attenuated recombinant modified vaccinia virus Ankara (rMVA), higher humoral and cellular immune responses to foreign antigens (human immunodeficiency virus type 1 Env and beta-galactosidase) were found in mice preimmunized with rMVA than in mice primed with the virulent Western Reserve strain and boosted with rMVA. This enhancement correlated with higher levels of expression of foreign antigens after the booster.

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Documento generato il 03/04/20 alle ore 20:38:30