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Titolo:
Treatment of immune-mediated hemolytic anemia in dogs with cyclophosphamide
Autore:
Burgess, K; Moore, A; Rand, W; Cotter, SM;
Indirizzi:
Tufts Univ, Sch Vet Med, Harrington Oncol Program, N Grafton, MA 01536 USATufts Univ N Grafton MA USA 01536 Oncol Program, N Grafton, MA 01536 USA Tufts Univ, Sch Med, N Grafton, MA USA Tufts Univ N Grafton MA USATufts Univ, Sch Med, N Grafton, MA USA
Titolo Testata:
JOURNAL OF VETERINARY INTERNAL MEDICINE
fascicolo: 4, volume: 14, anno: 2000,
pagine: 456 - 462
SICI:
0891-6640(200007/08)14:4<456:TOIHAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
alkylating agent; canine; immunosuppressive therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, A Tufts Univ, Sch Vet Med, Harrington Oncol Program, 200 Westboro Rd, N Grafton, MA 01536 USA Tufts Univ 200 Westboro Rd N Grafton MA USA 01536 n, MA 01536 USA
Citazione:
K. Burgess et al., "Treatment of immune-mediated hemolytic anemia in dogs with cyclophosphamide", J VET INT M, 14(4), 2000, pp. 456-462

Abstract

A review of 60 cases of immune-mediated hemolytic anemia (IMHA) in the dogwas performed in order to characterize the disease and to identify potential prognostic indicators. Dogs ranged in age from 1 to 13 years, with a mean age of 6.5 years. The 2 most commonly affected breeds were Cocker Spaniels and Labrador Retrievers. Fifty-two of the 60 dogs tested (87%) were autoagglutination positive and spherocytes were present in 45 (75%). Forty-one (89%) of 46 patients tested positive for the presence of immunoglobulin on the red blood cell surface (Coombs assay). The most common clinical signs atpresentation were lethargy, weakness, pale mucous membranes, icterus, hemoglobinuria, and anorexia. PCV less than 25% was present in 59 (98%) dogs. At the time of presentation. 35 dogs (58%) had a nonregenerative anemia whereas 25 patients (42%) had a regenerative response. Thrombocytopenia was seen in 41 (68%) dogs. Nine of 34 dogs (26%) had a prolonged prothrombin time,19 of 34 (56%) had a prolonged activated partial thromboplastin clotting time, and 12 of 34 (35%) had abnormal fibrinogen concentrations. All dogs received prednisone at immunosuppressive doses (2.2-4.4 mg/kg PO as a single or divided dose every 24 hours) and cyclophosphamide as primary therapy. Forty-one dogs (63%) received cyclophosphamide at 50 mg/m(2) q24h for 4 days,whereas 9 dogs (15%) received an initial high dose (200 mg/m(2)) followed by 3 days of a lower dose (50 mg/m(2) q24h). No statistical difference in survival times was found for either protocol. Thirteen does were treated with azathioprine in addition to cyclophosphamide and prednisone. The median survival time of dogs that received all 3 drugs was 370 days as compared to 9 days for those dogs that were treated with cyclophosphamide and prednisone alone. Thirty-one (52%) dogs died from the disease, 13 (22%) dogs were alive, and 15 (25%! dogs were lost to follow-up. The median length of survival for all dogs was 21 days. Eight dogs that were discharged from the hospital suffered a relapse (PCV < 25%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:05:13