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Titolo:
Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis
Autore:
Aten, J; Roos, A; Claessen, N; Schilder-Tol, EJM; Ten Berge, IJM; Weening, JJ;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Renal Transplant Unit, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 8, volume: 11, anno: 2000,
pagine: 1426 - 1438
SICI:
1046-6673(200008)11:8<1426:SASGLO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; VASCULAR ENDOTHELIAL-CELLS; T-CELLS; OX40 LIGAND; FACTOR-ALPHA; ACTIVATION MOLECULE; CIRCULATING LEVELS; ERYTHEMATOSUS SLE; DISEASE-ACTIVITY; FAS/APO-1 CD95;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Aten, J Univ Amsterdam, Acad Med Ctr, Dept Pathol, Meibergdreef 9,L2-256, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9,L2-256 Amsterdam Netherlands NL-1105 AZ
Citazione:
J. Aten et al., "Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis", J AM S NEPH, 11(8), 2000, pp. 1426-1438

Abstract

CD134 (OX40) is a member of the tumor necrosis factor (TNF) receptor (TNFR) family that can be expressed on activated T lymphocytes. Interaction between CD134 and its ligand (CD134L) is involved in costimulation of T and B lymphocyte activation, and in T cell adhesion to endothelium. To examine thepossible role of this interaction in the pathogenesis of systemic lupus erythematosus (SLE), expression of CD134 and CD134L on peripheral blood leukocytes was studied, and no significant differences between SLE patients and control individuals were found. Immunohistology on renal biopsies from patients with lupus nephritis or other renal disorders, using a recombinant human CD134-containing chimeric molecule to detect CD134L, demonstrated the abundant presence of CD134L in all cases of proliferative lupus nephritis in a granular distribution predominantly along the epithelial side of the glomerular capillary wall. Confocal laser scanning microscopy indicated colocalization with subepithelial immune deposits. In none of the other renal disorders examined, including nonproliferative forms of lupus nephritis, was glomerular staining for CD134L detected in a similar pattern. Endothelial CD134L expression was frequently observed in different types of vasculitis. CD134 was detected on perivascular infiltrating leukocytes and on part of thetubular epithelium, but not on glomerular resident cells. Immunohistology for several other TNF(R) family members revealed in proliferative lupus nephritis a similar distribution for TNFR1 as was observed for CD134L. In contrast, glomerular expression of TNFR2 was similar in all cases examined. Theglomerular presence of CD134L and TNFR1 in proliferative lupus nephritis in association with subepithelial immune deposits may be of pathogenetic significance and have diagnostic value.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:32:47