Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive effect of nimesulide
Autore:
Islas-Cadena, M; Aguirre-Banuelos, P; Granados-Soto, V;
Indirizzi:
Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacol & Toxicol, Mexico City 14000, DF, Mexico Inst Politecn Nacl Mexico City DF Mexico14000 ico City 14000, DF, Mexico Benemerita Univ Puebla, Fac Ciencias Quim, Puebla, Mexico Benemerita Univ Puebla Puebla Mexico Fac Ciencias Quim, Puebla, Mexico
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 2, volume: 42, anno: 1999,
pagine: 87 - 92
SICI:
1056-8719(199910)42:2<87:EFTPOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SENSORY NEURONS; PROTEIN-KINASE; NOCICEPTOR SENSITIZATION; PERIPHERAL ANALGESIA; SYNTHESIS INHIBITION; FORMALIN TEST; HYPERALGESIA; PAIN; INFLAMMATION; MODULATION;
Keywords:
nimesulide; nitric oxide; cyclic GMP; L-NAME; ODQ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Granados-Soto, V Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, DeptFarmacol & Toxicol, Apartado Postal 22026, Mexico City 14000, DF, Mexico Inst Politecn Nacl Apartado Postal 22026 Mexico City DF Mexico 14000
Citazione:
M. Islas-Cadena et al., "Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive effect of nimesulide", J PHARM TOX, 42(2), 1999, pp. 87-92

Abstract

The involvement of the nitric oxide-cyclic GMP pathway in the peripheral antinociception induced by the COX-2 preferential inhibitor nimesulide was assessed by using the formalin test in the rat. Intraplantar administration of nimesulide in the formalin-injured paw produced a significant antinociceptive effect that was due to a local action, because nimesulide administration in the contralateral paw was ineffective. Local pretreatment of the paws with saline or N-G-D-nitro-arginine methyl eater (D-NAME, the inactive isomer of L-NAME) did not affect the antinociception produced by nimesulide. However, local administration of L-NAME (a nitric oxide synthesis inhibitor) or H-1-(1,2,4)-oxadiazolo(4:2-a)quinoxalin-1 (ODQ: a soluble guanylyl cyclase inhibitor) blocked the effect of nimesulide. Moreover, the antinociceptive effect of local nimesulide was potentiated by the coadministration of 3-morpholino-sydnonimine-HCl (SIN-1, a nitric oxide donor). It is concludedthat nimesulide produces antinociception by a peripheral mechanism of action requiring activation of the nitric oxide-cyclic GMP pathway at the locallevel. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:11:17