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Titolo:
Remote episodic memory deficits in patients with unilateral temporal lobe epilepsy and excisions
Autore:
Viskontas, IV; McAndrews, MP; Moscovitch, M;
Indirizzi:
Toronto Western Hosp, Program Neurosci, Univ Hlth Network, Toronto, ON M5T2S8, Canada Toronto Western Hosp Toronto ON Canada M5T 2S8 Toronto, ON M5T2S8, Canada Univ Toronto, Dept Psychol, Univ Hlth Network, Toronto, ON M5T 2S8, CanadaUniv Toronto Toronto ON Canada M5T 2S8 twork, Toronto, ON M5T 2S8, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 20, anno: 2000,
pagine: 5853 - 5857
SICI:
0270-6474(20000801)20:15<5853:REMDIP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE-AMNESIA; HIPPOCAMPAL COMPLEX; CONSOLIDATION; LOBECTOMY; HUMANS; EVENTS;
Keywords:
remote memory; episodic memory; epilepsy; temporal gradient; multiple trace theory; consolidation; autobiographical memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: McAndrews, MP Toronto Western Hosp, Program Neurosci, Univ Hlth Network, EC2-009,399 Bathurst St, Toronto, ON M5T 2S8, Canada Toronto Western Hosp EC2-009,399 Bathurst St Toronto ON Canada M5T 2S8
Citazione:
I.V. Viskontas et al., "Remote episodic memory deficits in patients with unilateral temporal lobe epilepsy and excisions", J NEUROSC, 20(15), 2000, pp. 5853-5857

Abstract

The nature of remote memory impairment in patients with medial temporal lobe damage is the subject of some debate. While some investigators have found that retrograde amnesia in such patients is temporally graded, with relative sparing of remote memories (Squire and Alvarez, 1995), others contend that impairment is of very long duration and that remote memories are not necessarily spared (Sanders and Warrington, 1971; Nadel and Moscovitch, 1997). In this study, remote memory was assessed in 25 patients with unilateral temporal lobe epilepsy and 22 non-neurologically impaired controls using the Autobiographical Memory Interview (Kopelman et al., 1989). Results indicate that patients have impaired personal episodic memory but intact personalsemantic memory. The impairment extends even to the most remote time periods in early childhood, long before seizure onset in many patients. As well,patients awaiting temporal lobectomy for control of seizures perform as poorly as those who have already undergone resective surgery. These results support the hypothesis that temporal lobe damage or dysfunction, caused by recurrent seizures or surgical excision, results in extensive retrograde amnesia for personal episodic memories. Interestingly, patients with radiological evidence of hippocampal sclerosis were not significantly more impaired than those without obvious sclerosis. These results indicate that even minimal damage to medial temporal lobes results in significant impairment to autobiographical episodic memory. These findings are more compatible with a memory loss or retrieval deficit rather than a consolidation account of remote memory impairment.

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Documento generato il 23/09/20 alle ore 13:05:50