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Titolo:
Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiplesclerosis central nervous system tissue
Autore:
Simpson, J; Rezaie, P; Newcombe, J; Cuzner, ML; Male, D; Woodroofe, MN;
Indirizzi:
Sheffield Hallam Univ, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ Sheffield S Yorkshire England S1 1WB shire, England Sheffield Hallam Univ, Div Biomed Sci, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ Sheffield S Yorkshire England S1 1WB shire, England Inst Psychiat, Dept Neuropathol, London SE5 8AF, England Inst Psychiat London England SE5 8AF europathol, London SE5 8AF, England Inst Neurol, Neuroinflammat Grp, London WC1N 1PJ, England Inst Neurol London England WC1N 1PJ lammat Grp, London WC1N 1PJ, England Open Univ, Dept Biol Sci, Milton Keynes MK7 6AA, Bucks, England Open UnivMilton Keynes Bucks England MK7 6AA nes MK7 6AA, Bucks, England
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 108, anno: 2000,
pagine: 192 - 200
SICI:
0165-5728(20000801)108:1-2<192:EOTBRC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY CELLS; HIV-1 INFECTION; T-CELLS; LESIONS; BRAIN; MIP-1-ALPHA; MICROGLIA; LIGANDS; ENCEPHALOMYELITIS; LYMPHOCYTES;
Keywords:
beta-chemokine receptors; multiple sclerosis; astrocytes; macrophages; Th1 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, J Sheffield Hallam Univ, Biomed Res Ctr, City Campus,Pond St, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ City Campus,Pond St Sheffield S Yorkshire England S1 1WB
Citazione:
J. Simpson et al., "Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiplesclerosis central nervous system tissue", J NEUROIMM, 108(1-2), 2000, pp. 192-200

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterised by perivascular inflammatory cell infiltrates and plaques of demyelination. Chemokines have been shown to play an important role in the activation and directional migration of cells tosites of CNS inflammation. The action of chemokines requires the expression of their complementary chemokine receptors by their target cells. We haveexamined the expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in post-mortem MS CNS tissue using single- and double-labelling immunocytochemistry techniques. Low levels of CCR2. CCR3 and CCR5 were expressed by microglial cells throughout control CNS tissue. In chronic active MS lesions CCR2, CCR3 and CCR5 were associated with foamy macrophages and activated microglia. CCR2 and CCR5 were also present on large numbers of infiltratinglymphocytes. A smaller number of CCR3-positive lymphocytes were present, but we also noted CCR3 and CCR5 on astrocytes in five of the 14 cases of MS investigated, particularly associated with processes around vessels and at the glia limitans. Ligands fur CCR3 and CCR3 include MCP-1 and MCP-3 which were co-localised around vessels with the infiltrating leukocytes. but werealso present in unaffected areas of cortex. The elevated expression of CCR2, CCR3 and CCR5 in the CNS in MS suggests these beta-chemokine receptors and their ligands play a role in the pathogenesis of MS. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:21:16