Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis
Autore:
Wang, ZY; Diethelm-Okita, B; Okita, DK; Kaminski, HJ; Howard, JF; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USAUniv Minnesota Minneapolis MN USA 55455 iophys, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA Case Western Reserve Univ, Dept Neurol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ N Carolina, Dept Neurol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ina, Dept Neurol, Chapel Hill, NC USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 108, anno: 2000,
pagine: 29 - 39
SICI:
0165-5728(20000801)108:1-2<29:TCROMA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC GAMMA-SUBUNIT; ALPHA-SUBUNIT; PEPTIDE RECOGNITION; EXTRAOCULAR-MUSCLE; EPITOPE REPERTOIRE; HEALTHY-SUBJECTS; CD4(+); EXPRESSION; MODEL; MICE;
Keywords:
ocular myasthenia gravis; acetylcholine receptor; T cell recognition; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ Minnesota, Dept Biochem, 1479 Gortner Ave, St Paul, MN55108 USA Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 08 USA
Citazione:
Z.Y. Wang et al., "T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis", J NEUROIMM, 108(1-2), 2000, pp. 29-39

Abstract

We examined the proliferative response of blood CD4(+) cells to muscle acetylcholine receptor (AChR) subunits and the epitope repertoire of the epsilon and gamma subunits, in ocular myasthenia gravis (oMG) patients and healthy subjects. oMG patients seldom recognized all subunits. The frequency andintensity of recognition was the same for all subunits, irrespective of the disease duration. The responses in oMG were lower than in generalized myasthenia gravis. Healthy subjects had frequent, low responses to one or moresubunits. oMG patients recognized several epitopes on the gamma and epsilon subunits, that partially overlapped those recognized in gMG. The subunitsand epitopes recognized by individual oMG patients changed over time. Thus, oMG patients have minimal and unstable sensitization of anti-AChR CD4(+) cells, in agreement with their low and inconsistent synthesis of anti-AChR antibody. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/12/20 alle ore 00:00:41